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Ivosidenib is available as a 250 mg oral tablet.

Ivosidenib is a type of targeted therapy that is used to treat adults with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or bile duct cancer (cholangiocarcinoma).

Ivosidenib is an IDH1 inhibitor. It blocks the mutated version of the IDH1 protein from working.

For IDH1-mutated AML and MDS:

• Stopping mutated IDH1 from working helps prevent the body from making too many abnormal and immature white blood cells. This helps treat AML and MDS.
• For IDH1-mutated bile duct cancer (cholangiocarcinoma): Blocking mutated IDH1 stops the cancer cells from growing and spreading. This helps treat bile duct cancer.

The recommended dose of Ivosidenib is 500 mg orally once daily with or without food until disease progression or unacceptable toxicity. Avoid a high-fat meal.

Ivosidenib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Ivosidenib:

• Lower hemoglobin levels
• Changes in electrolyte levels
• Tiredness
• High white blood cell count
• Joint pain
• Diarrhea
• Trouble breathing
• Swelling
• Nausea
• Mouth sores
• Elevated liver enzyme levels
• Changes in electrocardiogram (EKG) results
• Rash
• Fever
• Higher creatinine levels
• Cough
• Constipation

Serious side effects are rare with Ivosidenib. Contact your healthcare provider immediately if you experience any of the following:

• Differentiation syndrome (for people with AML or MDS only): fever, sudden weight gain, trouble breathing, chest pain, swelling in legs
• Abnormal heart rhythm: irregular heartbeat, blurry vision, lightheadedness, fainting, loss of consciousness
• Guillain-Barré syndrome (GBS): weakness that starts in the legs, arms, or face and then progresses to other parts of the body, numbness and tingling, difficulty moving or walking, trouble breathing

The following medications may interact with Ivosidenib:

• CYP3A4 inhibitors, inducers, and substrates
• QTc Prolonging Drug

Various FDA-approved generic manufacturers

Ivosidenib can cause harm to your unborn baby. You should avoid becoming pregnant during treatment. Tell your healthcare provider right away if you become pregnant or think you might be pregnant while taking Ivosidenib.

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