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Increlex is the brand name for mecasermin and is available as a subcutaneous injection.

Increlex is available as a sterile solution supplied in a multiple dose glass vial at a concentration of 10 mg per mL (40 mg per vial).

Increlex is used to improve growth in children who are very short for their age because of severe primary IGF-1 deficiency or growth hormone (GH) deletion and have developed antibodies that attack GH.

Increlex is a recombinant insulin-like growth factor-1 (IGF-1). It’s a lab-made version of the natural hormone your body makes called IGF-1. Children with primary IGF-1 deficiency or GH gene deletion have very low levels of IGF-1. Because they don’t have enough IGF-1 in the body, these children can’t grow properly. Increlex helps raise their IGF-1 levels so that their growth can improve.

The dose of Increlex is based on your child’s weight. The typical starting dose is 0.04 mg/kg to 0.08 mg/kg injected under the skin twice a day. Your child’s prescriber might slowly raise the dose up to a maximum of 0.12 mg/kg twice a day as long as there aren’t side effects.

Increlex is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Known hypersensitivity to mecasermin
• Intravenous use
• Closed growth plate
• Currently have or have had cancer

Common side effects of Increlex:

• Low blood sugar
• Swollen tonsils
• Injection site reactions
• Headache
• Dizziness
• Uncontrolled muscle spasms
• Vomiting
• Joint pain
• Pain in the arm or leg
• Ear infection

Serious side effects are rare with . Contact your healthcare provider immediately if you experience any of the following:

• Dangerously low blood sugar: feeling faint, shaking, sweating, dizziness, fast heartbeat, nervousness, anxious, confused, irritable, feeling very hungry
• Serious allergic reaction: hives, rash, itching, dizziness, shaking, flushing, nausea, trouble breathing, chest pain, swelling of the face or mouth
• High pressure in the brain: changes in vision, headache, nausea, vomiting

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Ipsen Biopharmaceuticals, Inc.

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Mecasermin