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Iloprost is available as a 1 mL ampules in two concentrations: 10 mcg/mL and 20 mcg/mL.

Iloprost is a prostacyclin and is used to treat pulmonary arterial hypertension (PAH).

Iloprost is a lab-made medication that works similarly to the prostacyclin chemical that your body naturally makes. When it’s inhaled through the mouth, Iloprost helps to relax the blood vessels in the lungs, which allows more blood to flow through. As a result, the medication helps your body get more oxygen. This helps you breathe and exercise easier.

Iloprost comes in ampules. Each ampule contains 10 mcg or 20 mcg of Iloprost. With the I-neb AAD system, a 10 mcg ampule can deliver 2.5 mcg or 5 mcg of Iloprost for each treatment session, and a 20 mcg ampule can deliver 5 mcg of Iloprost for each treatment session. The typical starting dose is 2.5 mcg inhaled by mouth 6 to 9 times daily, about 2 hours apart. Your provider might raise your dose to 5 mcg inhaled 6 to 9 times daily (no more than once every 2 hours), depending on how well you tolerate the medication. The maximum total dose is 45 mcg daily (5 mcg inhaled 9 times daily).

Iloprost is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Iloprost:

• More coughing
• Headache
• Flushing
• Flu symptoms
• Nausea
• Lockjaw

Serious side effects are rare with Iloprost. Contact your healthcare provider immediately if you experience any of the following.

• Bronchospasm (sudden breathing problems): tightening of the throat, tightness in the chest, trouble breathing, wheezing, cough
• Chest pain
• Extremely low blood pressure: dizziness, fainting
• Symptoms of heart failure: shortness of breath, swelling in the legs and belly

The following medications may interact with Iloprost:

• Iloprost has the potential to increase the hypotensive effect of vasodilators and antihypertensive agents
• There is a potential for increased risk of bleeding, particularly in patients maintained on anticoagulants

Various FDA-approved generic manufacturers

It is not known if Iloprost can harm your unborn baby.
Iloprost should only be used during pregnancy if the benefit to you is worth the possible risk to
your baby.

• Aurlumyn
• Ventavis