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Ibrance is the brand name for palbociclib and is available as an oral capsule.

Ibrance is available as a 75 mg, 100 mg, and 125 mg oral capsule.

Ibrance is a kinase inhibitor and is used to treat HR+/HER2- advanced or metastatic breast cancer.

Ibrance is a specific type of kinase inhibitor, called a cyclin-dependent kinase 4 and 6 (CDK 4/6) inhibitor. CDK 4/6 are proteins that control cell growth in both normal and cancer cells. These proteins can become overactive in cancer cells and cause the cancer to uncontrollably divide and grow. By blocking CDK 4/6, Ibrance slows the growth of cancer cells.

Ibrance is typically dosed as 125 mg once daily taken with food for 21 days followed by 7 days off treatment.

Ibrance is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Ibrance:

• Infection
• Low white blood cell counts
• Tiredness
• Nausea
• Hair loss
• Swollen or sore mouth
• Low red blood cell count
• Diarrhea
• Low platelet counts

Serious side effects are rare with Ibrance. Contact your healthcare provider immediately if you experience any of the following.

• Serious infections: fever, chills, dizziness, shortness of breath, weakness, bruising or bleeding more often
• Lung problems: cough, trouble breathing, shortness of breath, chest pain

The following medications may interact with Ibrance:

• CYP3A Inhibitors: Avoid concurrent use of Ibrance with strong CYP3A inhibitors. If the strong inhibitor cannot be avoided, reduce the Ibrance dose
• CYP3A Inducers: Avoid concurrent use of Ibrance with strong CYP3A inducers
• CYP3A Substrates: The dose of sensitive CYP3A4 substrates with narrow therapeutic indices may need to be reduced when given concurrently with Ibrance

Pfizer

Ibrance can harm your unborn baby. Females who are able to become pregnant should use effective birth control during treatment and for at least 3 weeks after the last dose of Ibrance. Your healthcare provider may ask you to take a pregnancy test before you start treatment with Ibrance.
Males with female partners who can become pregnant should use effective birth control during treatment with Ibrance for at least 3 months after the last dose of Ibrance. Talk to your healthcare provider about birth control methods that may be right for you during this time. If you become pregnant or think you are pregnant, tell your healthcare provider right away.

• Palbociclib