HUMULIN R U-500
Used for Type 2 Diabetes and Type 1 Diabetes
NowPatient helps you obtain your HUMULIN R U-500 prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Eli Lilly & Company
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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HUMULIN R U-500 key facts
What is HUMULIN R U-500?
HUMULIN R U-500 is the brand name for insulin human and is available as a subcutaneous injection.
What dosages is HUMULIN R U-500 available in?
HUMULIN R U-500 is available as a vial and Kwikpen that contains 500 units/ml.
What is HUMULIN R U-500 used for?
HUMULIN R U-500 is an insulin and is used for the following:
- Type 1 diabetes
- Type 2 diabetes
How does HUMULIN R U-500 work?
HUMULIN R U-500 is an insulin. Insulin is a hormone that lowers glucose (sugar) levels in the blood. It helps your body absorb and store sugar and fat from your bloodstream after eating a meal.
How do I take HUMULIN R U-500?
- HUMULIN R U-500 is injected underneath the skin (subcutaneously) about 30 minutes before each meal. The dose of HUMULIN R U-500 is different for each person so your healthcare provider will provide you with directions on how many units of HUMULIN R U-500 to inject. The dose depends on whether you’re using it for type 1 diabetes or type 2 diabetes, your weight, how well you respond to insulin, and your blood sugar levels
Is it safe for me to take HUMULIN R U-500?
HUMULIN R U-500 is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have symptoms of hypoglycemia.
HUMULIN R U-500 Common Side Effects
Common side effects of HUMULIN R U-500:
- Low blood sugar (hypoglycemia)
- Injection site reactions (e.g., redness, warmth, changes in skin color)
- Lipodystrophy (buildup or loss of fat tissue)
- Weight gain
- Edema (swelling)
- Itchy skin
- Skin rash
HUMULIN R U-500 Serious Side Effects
Serious side effects are rare with HUMULIN R U-500. Contact your healthcare provider immediately if you experience any of the following.
- Severe hypoglycemia (dangerously low blood sugar) – If not treated, severe hypoglycemia can lead to unconsciousness, seizures, and even death
- Severe allergic reactions
- Dangerously low levels of potassium
Effects of other drugs, drug classes and over-the-counter products on HUMULIN R U-500
The following medications may interact with HUMULIN R U-500:
- Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g. octreotide), and sulfonamide antibiotics
- Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics estrogens, glucagon, isoniazid, niacin, oral contraceptives phenothiazines, progestogens (e.g., in oral contraceptives) protease inhibitors, somatropin, sympathomimetic agents (e.g. albuterol, epinephrine, terbutaline), and thyroid hormones
- Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine
- Drugs that may blunt the signs and symptoms of hypoglycemia: beta-blockers, clonidine, guanethidine, and reserpine
Who makes HUMULIN R U-500?
Eli Lilly & Company
Is HUMULIN R U-500 safe in pregnancy?
Published studies with HUMULIN R U-500 used during pregnancy have not reported an association between insulin lispro and the induction of major birth defects, miscarriage, or adverse maternal or fetal outcomes. If you become pregnant while receiving HUMULIN R U-500, talk to your healthcare provider.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my HUMULIN R U-500 prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your HUMULIN R U-500 prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient HUMULIN R U-500 savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient HUMULIN R U-500 savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for HUMULIN R U-500 | Canadian Prescription Savings* for HUMULIN R U-500 | HUMULIN R U-500 Drug Coupon* | HUMULIN R U-500 Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of HUMULIN R U-500?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for HUMULIN R U-500 | Canadian Prescription Savings* for HUMULIN R U-500 | HUMULIN R U-500 Drug Coupon* | HUMULIN R U-500 Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the HUMULIN R U-500 savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the HUMULIN R U-500 drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for HUMULIN R U-500, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the HUMULIN R U-500 prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, HUMULIN R U-500 is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed HUMULIN R U-500 for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the HUMULIN R U-500 prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the HUMULIN R U-500 prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for HUMULIN R U-500
If you are having trouble paying for your HUMULIN R U-500 medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for HUMULIN R U-500 you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- HUMULIN R U-500 is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers HUMULIN R U-500
- If HUMULIN R U-500 is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for HUMULIN R U-500
If you are having trouble paying for your HUMULIN R U-500 medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for HUMULIN R U-500 you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers HUMULIN R U-500
- If HUMULIN R U-500 is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for HUMULIN R U-500
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your HUMULIN R U-500 treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for HUMULIN R U-500 you will need to meet the following criteria:
- You must be currently insured and have coverage for HUMULIN R U-500
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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