GAVRETO
Used for Cancer
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Manufactured by Genentech, Inc.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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GAVRETO Uses, Side Effects, Interactions, Warnings & Dosing
What is GAVRETO?
GAVRETO is the brand name for pralsetinib oral capsules.
What dosages is GAVRETO available in?
GAVRETO is available as a 100 mg oral capsule.
What is GAVRETO used for?
GAVRETO is an RET kinase inhibitor that is used to treat:
Metastatic NSCLC with RET gene fusion in adults
Advanced or metastatic thyroid cancers with RET mutations, in adults and children 12 years of age or older
How does GAVRETO work?
GAVRETO interrupts tumor growth by blocking these abnormal RET proteins from sending the growth signal.
How do I take GAVRETO?
The typical dose is 400 mg by mouth daily on an empty stomach.
Is it safe for me to take GAVRETO?
GAVRETO is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
GAVRETO Common Side Effects
Common side effects of GAVRETO:
- Lower electrolyte levels (calcium, sodium, magnesium, phosphate)
- Labs suggesting liver or kidney problems
- Muscle, bone, or joint pain
- Constipation
- High blood pressure
- Feeling very tired
- Diarrhea
GAVRETO Serious Side Effects
Serious side effects are rare with GAVRETO. Contact your healthcare provider immediately if you experience any of the following.
- Lung inflammation: cough, shortness of breath, fever
- Liver injury: pain in the right side of the stomach, yellowing of the eyes or skin, dark or brown urine
- High blood pressure: headache, dizziness, confusion, chest pain
- Severe bleeding: sudden or painful headache, changes in vision, severe stomach pain, coughing or spitting up blood
- Tumor lysis syndrome: muscle cramps, dark or brown urine, fluttering or pounding heart beat
Effects of other drugs, drug classes and over-the-counter products on GAVRETO
The following medications may interact with GAVRETO:
- Strong or moderate CYP3A inhibitors and/or P-gp inhibitors: Avoid coadministration. If coadministration cannot be avoided, reduce the dose of GAVRETO
- Strong or moderate CYP3A inducers: Avoid coadministration. If coadministration cannot be avoided, increase the dose of GAVRETO
Who makes GAVRETO?
Genentech, Inc.
Is GAVRETO safe in pregnancy?
GAVRETO can harm your unborn baby. Females who are able to become pregnant: Your healthcare provider will do a pregnancy test before you start treatment with GAVRETO.
You should use an effective form of non-hormonal birth control (contraception) during treatment and for 2
weeks after your last dose of GAVRETO. Birth control methods that contain hormones (such as birth control pills, injections or transdermal system patches) may not work as well during treatment with GAVRETO. Talk to your healthcare provider about birth control methods that may be right for you during this time. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during
treatment with GAVRETO. Males with female partners who are able to become pregnant: You should use effective birth control (contraception) during treatment and for 1 week after your last dose of GAVRETO.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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