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Fotivda is the brand name for tivozanib and is available as an oral capsule.

Fotivda is available in a 1.34 mg and 0.89 mg oral capsule.

Fotivda is a targeted therapy used to treat adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies.

Fotivda is a kinase inhibitor. More specifically, it blocks vascular endothelial growth factor receptors (VEGFRs). These are proteins in cancer cells that provide blood supply to the tumor. By blocking these proteins, Fotivda prevents blood vessels from forming and supplying blood to the tumor. This helps to slow and stop cancer growth.

The recommended dose of Fotivda is 1.34 mg once daily with or without food for 21 days followed by 7 days off (28-day cycle) until disease progression or unacceptable toxicity.

Fotivda is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Fotivda:

• Fatigue
• Higher creatinine levels
• Higher blood sugar levels
• High blood pressure
• Diarrhea
• Lowered appetite
• Lower phosphate levels
• Lower sodium levels
• Higher lipase levels
• Nausea
• Higher liver enzyme levels
• Hoarseness
• Higher potassium levels
• Lower magnesium levels

Serious side effects are rare with Fotivda. Contact your healthcare provider immediately if you experience any of the following:

• Heart failure: chest pounding, chest pain, trouble catching your breath, feeling faint or lightheaded, swelling in the legs
• Serious bleeding (general): unusual bleeding, bleeding that’s difficult to stop, easy bruising, blood in urine or stool
• Blood clot in the lungs: cough, chest pain, trouble breathing, racing heart
• Blood clot in the heart: chest pain, stomach discomfort, sweating, nausea, dizziness
• Blood clot in the leg: leg cramp, swelling, pain, muscle tightness
• Dangerously high blood pressure: anxiety, blurry vision, confusion, chest pain, nausea, vomiting, headache

The following medications may interact with Fotivda:

• Strong CYP3A inducers

Aveo Pharmaceuticals

Fotivda may harm your unborn baby. If you’re a female who’s can get pregnant, you should take a pregnancy test before you start treatment. Males and females who are taking Fotivda should use effective birth control while on this medication and for 1 month after the last dose. Let your doctor know right away if you or your partner become pregnant during this time.

• Tivozanib