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Evinacumab-Dgnb is available as a 345 mg/2.3 mL (150 mg/mL) and 1,200 mg/8 mL (150 mg/mL) solution in single-dose vials.

Evinacumab-Dgnb is a monoclonal antibody that treats homozygous familial hypercholesterolemia (HoFH), a rare genetic condition that causes extremely high cholesterol levels.

Evinacumab-Dgnb is a monoclonal antibody that works as an angiopoietin-like 3 (ANGPTL3) inhibitor. ANGPTL3 is a protein in your liver that normally stops your body from getting rid of triglycerides (fat) and low-density lipoprotein (LDL, also known as “bad” cholesterol). By blocking the ANGPTL3 protein, Evinacumab-Dgnb allows your body to break down and remove triglycerides and LDL.

The recommended dosage of Evinacumab-Dgnb is 15 mg/kg administered by intravenous (IV) infusion once monthly (every 4 weeks).

Evinacumab-Dgnb is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• History of serious hypersensitivity reactions to Evinacumab-Dgnb or to any of the excipients in the product

Common side effects of Evinacumab-Dgnb:

• Common cold symptoms
• Flu-like symptoms
• Dizziness
• Runny nose
• Nausea
• Constipation
• Stomach pain
• Pain in arms or legs
• Weakness

Serious side effects are rare with Evinacumab-Dgnb. Contact your healthcare provider immediately if you experience any of the following:

• Severe allergic reaction: swelling of the lips, tongue, or throat; breathing problems; feeling dizzy; fainting; itchiness; anaphylaxis

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Evinacumab-Dgnb may harm your unborn baby. Tell your healthcare provider if you become pregnant while using this medication. People who are able to become pregnant should have a pregnancy test before you start treatment. You should use an effective form of birth control during treatment and for at least 5 months after the last dose.

• Evkeeza