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Epidiolex is the brand name for cannabidiol and is available as an oral solution.

Epidiolex is available as a 100 mg/mL oral solution.

Epidiolex is indicated for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex in patients 1 year of age and older.

Epidiolex is a cannabinoid (CBD) that comes from the Cannabis sativa plant (marijuana). The way it works to treat seizures isn’t known, but it’s thought to work on receptors in the brain to help calm brain cells down.

Your dose of Epidiolex depends on what condition you’re treating:

• Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS): The typical starting dose is 2.5 mg/kg of body weight by mouth twice daily. After one week, your neurologist might raise your dose to 5 mg/kg twice daily. The maximum dose is typically 10 mg/kg twice daily.
• Tuberous sclerosis complex (TSC): The typical starting dose is 2.5 mg/kg by mouth twice daily. Your neurologist will raise your dose slowly until you reach a maintenance dose of 12.5 mg/kg twice daily.
• Your dose might differ if you have liver problems.

Epidiolex is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Hypersensitivity to cannabidiol or any of the ingredients in the product

Common side effects of Epidiolex:

• Infection
• Drowsiness
• Poor appetite
• Diarrhea
• Increased liver enzymes
• Fatigue
• Weakness
• Trouble sleeping

Serious side effects are rare with Epidiolex. Contact your healthcare provider immediately if you experience any of the following:

• Suicidal thoughts or actions
• Serious allergic reaction: trouble breathing, swelling of your face or tongue, hives, rash
• Liver damage: yellowing of the skin or eyes (jaundice), nausea, feeling tired, itching, diarrhea, tenderness on the right side of your stomach

The following medications may interact with Epidiolex:

• Strong inducer of CYP3A4 or CYP2C19 Substrates of CYP1A2, CYP2C8, UGT1A9, and orally administered P-gp substrates.
• Everolimus
• CYP2B6 or CYP2C19 substrates

Jazz Pharmaceuticals, Inc.

Based on animal data, Epidiolex may cause fetal harm. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Cannabidiol