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Enhertu is the brand name for fam-trastuzumab deruxtecan-nxki and is available as an intravenous infusion.

Enhertu contains 100 mg of active ingredient in a single-dose vial.

Enhertu is used to treat adults with certain cancers that have a protein called HER2 on tumor cells. These cancers include breast cancer, non-small cell lung cancer (NSCLC), stomach cancer, esophageal cancer, and other solid tumors.

Enhertu is a targeted therapy called an antibody-drug conjugate (ADC). Fam-trastuzumab or trastuzumab is a monoclonal antibody. It targets a protein that’s found on cancer cells called HER2. This means that the antibody guides Enhertu specifically to the cancer cells with the HER2 protein on it. Once Enhertu reaches and enters the cancer cell, the chemotherapy part of the medication (called deruxtecan or DXd) works as a topoisomerase inhibitor. DXd damages the DNA in the cancer cell, which kills the cancer cell. This helps stop the cancer from growing or spreading as easily.

Your Enhertu dose depends on your cancer and body weight.

Breast cancer, NSCLC, or solid tumors:

• The typical dose is 5.4 mg/kg of weight IV once every 3 weeks (on day 1 of each 21-day treatment cycle).
• Stomach or esophageal cancer: The typical dose is 6.4 mg/kg of weight IV once every 3 weeks (on day 1 of each 21-day treatment cycle).

Enhertu is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Enhertu:

• Nausea
• Low blood cell counts
• Feeling very tired
• Elevated liver enzyme levels
• Vomiting
• Hair loss
• Constipation
• Low appetite
• Low potassium levels
• Diarrhea
• Muscle, bone, or joint pain
• Stomach pain

Serious side effects are rare with Enhertu. Contact your healthcare provider immediately if you experience any of the following:

• Lung damage: cough, having trouble catching your breath, wheezing, fever
• Low white blood cells and a risk for infection: fever, chills, feeling generally unwell
• Lower heart function: cough, fatigue, having trouble catching your breath, dizziness, swelling in the legs, sudden weight gain, irregular heartbeat

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

AstraZeneca

If you or your partner can get pregnant, use effective birth control during treatment with Enhertu. Continue using birth control for 7 months after your last dose if you’re female and for 4 months after your last dose if you’re male. Enhertu can harm an unborn baby if it’s taken during pregnancy.

• Fam-Trastuzumab Deruxtecan-Nxki