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Enbrel is the brand name for etanercept subcutaneous injection.

Enbrel is available as a 50 mg single-use prefilled syringe, 50 mg single-use prefilled SureClick® Autoinjector, 25 mg single-use prefilled syringe and 25 mg multiple-use vial.

Enbrel is a monoclonal antibody that is used to treat:

• Rheumatoid arthritis (RA)
• Plaque psoriasis (PsO) and psoriatic arthritis (PsA)
• Ankylosing spondylitis (AS)
• Childhood arthritis (polyarticular juvenile idiopathic arthritis, JIA)

Enbrel is a monoclonal antibody. It binds to a protein called TNF and blocks inflammation to help with symptoms of certain types of arthritis and skin conditions.

Enbrel is dosed as follows:

Adults

• Rheumatoid and psoriatic arthritis, ankylosing spondylitis: The typical dose is 50 mg injected under the skin once a week
• Plaque psoriasis: The starting dose is 50 mg injected under the skin twice a week for 3 months. Afterwards, your provider will lower your dose to 50 mg per week

Children

• Plaque psoriasis and polyarticular juvenile idiopathic arthritis: The dose will be based on the child’s weight
• 63 kg (138 lbs) or more: The typical dose is 50 mg injected under the skin once per week.
• Less than 63 kg (138 lbs): The typical dose is 0.8 mg/kg injected under the skin once per week

Enbrel is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have sepsis.

Common side effects of Enbrel:

• Infection (including common cold/flu)
• Injection site reaction
• Diarrhea

Serious side effects are rare with Enbrel. Contact your healthcare provider immediately if you experience any of the following.

• Serious infections: High fever, difficulty breathing, cough that won’t go away, night sweats, confusion
• Allergic reactions: Difficulty breathing, face swelling, fast heartbeat, severe rash

The following medications may interact with Enbrel:

• Live vaccines – should not be given with Enbrel.
• Anakinra – increased risk of serious infection.
• Abatacept – increased risk of serious adverse events, including
• infections.
• Cyclophosphamide – use with Enbrel is not recommended.

Amgen Inc.

Enbrel may cause harm to your unborn baby based on animal data. Enbrel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
To monitor outcomes of pregnant women exposed to Enbrel, a pregnancy registry has been established. Physicians are encouraged to register patients by calling 1-877-311-8972.

• Etanercept