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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

empagliflozin/metformin Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is empagliflozin/metformin available in?

What dosages is empagliflozin/metformin available in?

empagliflozin/metformin is an extended-release oral tablet that contains:

  • 5 mg empagliflozin/1,000 mg metformin
  • 10 mg empagliflozin/1,000 mg metformin
  • 12.5 mg empagliflozin/1,000 mg metformin or
  • 25 mg empagliflozin/1,000 mg metformin
What is empagliflozin/metformin used for?

What is empagliflozin/metformin used for?

empagliflozin/metformin is a SGLT2 inhibitor/biguanide combination that is used for the following:

  • Type 2 diabetes
  • Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
  • Lowering the risk of hospitalization and death due to heart problems in adults with Type 2 diabetes and heart failure
How does empagliflozin/metformin work?

How does empagliflozin/metformin work?

empagliflozin/metformin is a combination of two medications:
Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works in the kidneys to prevent sugar and sodium (salt) from absorbing back into your body. It lowers blood sugar by causing your body to get rid of excess sugar through your urine. By preventing sodium reabsorption, the heart fills with blood easier and pumps blood more easily throughout the body. Metformin is a biguanide. It lowers the amount of sugar that your liver makes. It also lowers the amount of sugar absorbed through the intestines. In addition, it makes your body more sensitive to a hormone called insulin. This means your cells are better able to take up sugar from the bloodstream and use it as energy.

How do I take empagliflozin/metformin?

How do I take empagliflozin/metformin?

  • Your dose of empagliflozin/metformin will depend on your current medications — whether you’re currently taking either Jardiance (empagliflozin), metformin, or both
  • Dosing for people who currently aren’t taking either Jardiance (empagliflozin) or metformin is listed below
  • Synjardy
  • Adults and children 10 years and older: The typical dose ranges from 5 mg/500 mg (empagliflozin / metformin) to 12.5 mg/1,000 mg (empagliflozin / metformin) by mouth twice daily with food. The maximum dose is 12.5 mg/1,000 mg (empagliflozin / metformin) twice daily
  • empagliflozin/metformin
  • Adults only: The typical starting dose is 10 mg/1000 mg (empagliflozin / metformin) by mouth once daily in the morning with food. The maximum dose is 25 mg/2,000 mg (empagliflozin / metformin) once daily
Is it safe for me to take empagliflozin/metformin?

Is it safe for me to take empagliflozin/metformin?

empagliflozin/metformin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:
Severe renal impairment (eGFR below 30 mL/min/1.73 m2), end stage renal disease, or on dialysis. Metabolic acidosis, including diabetic ketoacidosis.Hypersensitivity to empagliflozin, metformin or any of the excipients in
SYNJARDY or empagliflozin/metformin.

empagliflozin/metformin Common Side Effects

empagliflozin/metformin Common Side Effects

Common side effects of empagliflozin/metformin:

  • Low blood sugar
  • Urinary tract infections
  • Upper respiratory tract infection or common cold symptoms (e.g., cough, runny nose)
  • Vaginal yeast infection in females
  • Genital fungal infections in males
  • Joint pain
  • Frequent urination
  • Nausea
  • Vomiting
  • Diarrhea
empagliflozin/metformin Serious Side Effects

empagliflozin/metformin Serious Side Effects

Serious side effects are rare with empagliflozin/metformin. Contact your healthcare provider immediately if you experience any of the following.

  • Buildup of lactic acid: confusion, feeling weak, fast heartbeat, rapid breathing, no appetite, nausea, vomiting
  • Ketoacidosis (high ketone levels in the blood): shortness of breath, vomiting, belly pain, dry skin, dry mouth, feeling very tired, fruity-smelling breath
  • Sudden kidney problems: urinating less than usual, chest pain
  • Low blood pressure: dizziness, lightheadedness, confusion
  • Serious genital infection: pain, swelling, or redness in the genital area; fever; weakness
  • Severe allergic reactions: rash, blisters, sores, trouble breathing, swelling
Effects of other drugs, drug classes and over-the-counter products on empagliflozin/metformin

Effects of other drugs, drug classes and over-the-counter products on empagliflozin/metformin

The following medications may interact with empagliflozin/metformin:

  • Carbonic Anhydrase Inhibitors: May increase risk of lactic acidosis
  • Consider more frequent monitoring.
  • Drugs that Reduce Metformin Clearance: May increase risk of lactic acidosis. Consider benefits and risks of concomitant use
  • See full prescribing information for additional drug interactions and information on interference of SYNJARDY or empagliflozin/metformin with laboratory tests
Who makes empagliflozin/metformin?

Who makes empagliflozin/metformin?

Various FDA-approved generic manufacturers

Is empagliflozin/metformin safe in pregnancy?

Is empagliflozin/metformin safe in pregnancy?

Based on animal data showing adverse renal effects from empagliflozin, SYNJARDY and empagliflozin/metformin are
not recommended during the second and third trimesters of pregnancy.


What to do if you missed your empagliflozin/metformin dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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