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Eluxadoline is available as a 75 mg and 100 mg oral tablet.

Eluxadoline is an antidiarrheal and is used to treat irritable bowel syndrome with diarrhea (IBS-D).

Eluxadoline is an antidiarrheal medication that attaches to opioid receptors in the intestines (gut) and helps treat abdominal pain and diarrhea for patients with irritable bowel syndrome with diarrhea.

Eluxadoline is typically started at 100 mg by mouth twice a day with food. Some people cannot tolerate the 100 mg dose, or may have liver or kidney problems. For these people, the recommended dose is 75 mg by mouth twice a day with food.

Eluxadoline is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you any of the following applies:

• Patients without a gallbladder
• Known or suspected biliary duct obstruction, or sphincter of Oddi disease or dysfunction
• Alcoholism, alcohol abuse, alcohol addiction, or drink more than 3 alcoholic beverages/day
• A history of pancreatitis; structural diseases of the pancreas, including known or suspected pancreatic duct obstruction
• Patients with a known hypersensitivity reaction to Eluxadoline
  Severe hepatic impairment (Child-Pugh Class C).
  A history of chronic or severe constipation or sequelae from constipation, or known or suspected mechanical gastrointestinal obstruction

Common side effects of Eluxadoline:

• Constipation
• Nausea
• Abdominal pain

Serious side effects are rare with Eluxadoline. Contact your healthcare provider immediately if you experience any of the following.

• Pancreatitis: severe abdominal pain that starts from your back or shoulder

The following medications may interact with Eluxadoline:

• See full prescribing information for clinically relevant interactions

Various FDA-approved generic manufacturers

It is not known if Eluxadoline will harm your unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

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