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MEDICAL INFORMATION
Duvyzat Key Facts
What is Duvyzat?
Duvyzat (givinostat) is an oral suspension used to treat muscular dystrophy.
What dosages is Duvyzat available in?
Duvyzat is available as a 8.86 mg/mL oral suspension.
What is Duvyzat used for?
Duvyzat is a histone deacetylase inhibitor indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients 6 years of age and older.
How does Duvyzat work?
Duvyzat is a histone deacetylase inhibitor, which means it blocks a protein called histone deacetylase from working. People with DMD are thought to have higher histone deacetylase activity in their weakening muscles. By blocking these proteins, Duvyzat (givinostat) helps muscles rebuild and reduces inflammation.
How do I take Duvyzat?
The dose of Duvyzat is based on the patient ‘s body weight and is given by mouth twice daily with food. Dose adjustments may be needed for decreased platelet counts, diarrhea, increased triglycerides, or QTc prolongation.
Is it safe for me to take Duvyzat?
Duvyzat is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
Duvyzat Common Side Effects
Common side effects of Duvyzat: Diarrhea Stomach pain Low platelet counts in blood Nausea/vomiting Increase levels of fat in your blood Fever Muscle Pain Joint pain
Duvyzat Serious Side Effects
Serious side effects are rare with Duvyzat. Contact your healthcare provider immediately if you experience any of the following: Serious Bleeding: nosebleeds, excessive bleeding, unusual bleeding, blood in stool, tiredness Abnormal heart rhythm: heart pounding, dizziness, light headedness, passing out Severe diarrhea and vomiting: headache, increased thirst, dark-yellow urine, severe stomach pains
Effects of other drugs, drug classes and over-the-counter products on Duvyzat
The following medications may interact with Duvyzat: Closely monitor when Duvyzat is used in combination with an oral CYP3A4 substrates or substrates of the OCT2 transporter, for which a small change in substrate plasma concentration may lead to serious toxicities. Avoid concomitant use with other drugs that prolong the QTc interval; monitor ECG if concomitant use cannot be avoided
Who makes Duvyzat?
Merck
Is Duvyzat safe in pregnancy?
It is not known whether Duvyzat will harm your unborn baby. Talk with your healthcare provider about the risks of taking this medication if you are pregnant or plan on becoming pregnant.
What is the generic name for Duvyzat?
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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