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Donepezil is available as a 5 mg, 10 mg, 23 mg oral tablet and a 5 mg and 10 mg oral disintegrating tablet.

Donepezil is an acetylcholinesterase inhibitor indicated for the treatment of
dementia of the Alzheimer’s type.

Donepezil is a acetylcholinesterase inhibitor. Researchers don’t know exactly how it helps treat Alzheimer’s disease, but the medication prevents the breakdown of a chemical called acetylcholine. Acetylcholine is important in transmitting signals through nerves in the brain for learning and memory.

Donepezil is typically taken by mouth once daily.

Donepezil is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you have a known hypersensitivity to Donepezil hydrochloride or to piperidine derivatives.

Common side effects of Donepezil include:

• Nausea
• Diarrhea
• Headache
• Trouble sleeping
• Pain
• Dizziness
• Muscle cramps
• Tiredness
• Vomiting
• Loss of appetite

Serious side effects are rare with Donepezil. Contact your healthcare provider immediately if you experience any of the following.

• Symptoms of active or occult gastrointestinal (GI) bleeding
• Seizures
• Slow heart rate
• Trouble urinating

The following medications may interact with Donepezil:

• Cholinesterase inhibitors have the potential to interfere with the activity of anticholinergic medications. A synergistic effect may be expected with concomitant administration of succinylcholine, similar neuromuscular blocking agents, or cholinergic agonists

Various FDA-approved generic manufacturers

Donepezil may cause harm to your unborn baby, based on animal studies. Talk with your healthcare provider about the risks of taking Donepezil if you become pregnant.

• Aricept