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Deutetrabenazine is available as a 6 mg, 9 mg, and 12 mg oral tablet.

Deutetrabenazine is a VMAT2 inhibitor that is used to treat Chorea associated with Huntington’s disease and tardive dyskinesia.

Deutetrabenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor. It is not known exactly how this medication works. It is thought that Deutetrabenazine blocks a protein in your nerves called VMAT2. This helps lower the amount of certain chemicals in your nerves. Lowering these chemicals in your nerves might help with movement problems.

The typical starting dose of Deutetrabenazine is 6 mg by mouth twice daily. Your doctor may increase your dose weekly if needed, up to 24 mg twice daily. This dose may be changed if you take certain medications or have certain genes that increase Deutetrabenazine levels in your body.

Deutetrabenazine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Suicidal, or untreated/inadequately treated depression in patients with Huntington’s disease.
• Liver impairment
• Taking reserpine, MAOIs, tetrabenazine, or valbenazine

Common side effects of Deutetrabenazine:

• Sleepiness
• Diarrhea
• Dry mouth
• Tiredness
• Urinary tract infection (UTI)
• Trouble sleeping
• Common cold symptoms

Serious side effects are rare with Deutetrabenazine. Contact your healthcare provider immediately if you experience any of the following:

• Suicidal thoughts and behaviors
• Symptoms of neuroleptic malignant syndrome: high fever, sweating, stiff muscles, confusion, not aware of your surroundings, uneven heartbeat
• Abnormal movements: restlessness, can’t sit still, squirmy or fidgety, stiff muscles, slow movement, tremors, trouble keeping your balance

The following medications may interact with Deutetrabenazine:

• Strong CYP2D6 inhibitors; Maximum recommended dose of Deutetrabenazine is 36 mg per day
• Alcohol or other sedating drugs

Various FDA-approved generic manufacturers

Based on animal data, Deutetrabenazine may cause fetal harm. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Austedo
• Austedo XR