darbepoetin alfa
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Manufactured by various FDA-approved generic manufacturers.
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darbepoetin alfa Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is darbepoetin alfa available in?
darbepoetin alfa is available in:
- 25 mcg, 40 mcg, 60 mcg, 100 mcg, 200 mcg and 300 mcg single-dose vials
- 10 mcg/0.4 mL, 25 mcg/0.42 mL, 40 mcg/0.4 mL, 60 mcg/0.3 mL, 100 mcg/0.5 mL, 150 mcg/0.3 mL, 200 mcg/0.4 mL, 300 mcg/0.6 mL, and 500 mcg/1 mL single-dose prefilled syringes.
What is darbepoetin alfa used for?
darbepoetin alfa is an erythropoiesis-stimulating agent (ESA) that is used to treat:
- Anemia due to chemotherapy
- Anemia due to chronic kidney disease (dialysis and non-dialysis)
How does darbepoetin alfa work?
darbepoetin alfa is an erythropoiesis-stimulating agent (ESA). It works similarly to a naturally-occurring hormone in our body (erythropoietin). Erythropoietin sends a signal to our body to make more red blood cells.
How do I take darbepoetin alfa?
Your provider will determine your dose based on factors such as your body weight, age, and hemoglobin level.
Anemia due to chemotherapy
- The typical starting dose is 2.25 mcg/kg injected under the skin every week, or 500 mcg every 3 weeks until chemotherapy is finished
Anemia due to CKD
- Adults (not receiving dialysis): The typical recommended starting dose is 0.45 mcg/kg body weight injected under the skin or through the veins once every 4 weeks
- Adults (receiving dialysis): The typical recommended starting dose is 0.45 mcg/kg body weight injected under the skin or through the veins once a week, or 0.75 mcg/kg injected once every 2 weeks
- Children: The typical recommended starting dose is 0.45 mcg/kg body weight injected under the skin or through the veins once a week. If not receiving dialysis, the usual starting dose is 0.75 mcg/kg injected once every 2 weeks
Is it safe for me to take darbepoetin alfa?
darbepoetin alfa is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
Uncontrolled hypertension.
Pure red cell aplasia (PRCA) that begins after treatment with darbepoetin alfa or other erythropoietin protein drugs.
Serious allergic reactions to darbepoetin alfa.
darbepoetin alfa Common Side Effects
Common side effects of darbepoetin alfa:
- High blood pressure
- Trouble breathing
- Swelling in the hands and legs
- Cough
darbepoetin alfa Serious Side Effects
Serious side effects are rare with darbepoetin alfa. Contact your healthcare provider immediately if you experience any of the following.
- Seizures
- Heart attack: chest pain, stomach discomfort, sweating, nausea, dizziness
- Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, difficulty walking
- Dangerously high blood pressure: nausea, vomiting, confusion, dizziness, blurry vision, anxiety
- Heart failure: tiredness, weakness, trouble breathing, swelling in the ankles and feet, chest pain
- Serious allergic reaction: swelling of the face or tongue, throat tightening, trouble breathing, welts, skin rash
- Serious skin reactions: fever, sore throat, tiredness, trouble swallowing, cough, body aches, rash, peeling or blistering skin
Effects of other drugs, drug classes and over-the-counter products on darbepoetin alfa
There are no major drug interactions listed for darbepoetin alfa. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes darbepoetin alfa?
Various FDA-approved generic manufacturers
Is darbepoetin alfa safe in pregnancy?
It is not known if darbepoetin alfa may harm your unborn baby. Talk to your healthcare provider about possible pregnancy and birth control choices that are right for you.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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