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Daprodustat is available as a 1 mg, 2 mg, 4 mg, 6 mg, and 8 mg oral tablet.

Daprodustat is a HIF-PH inhibitor used to treat anemia due to chronic kidney disease (CKD) in adults who’ve been on dialysis for at least 4 months.

Daprodustat is a hypoxia-inducible factor–prolyl hydroxylase (HIF-PH) inhibitor. It helps prevent your body from breaking down HIF, a protein that responds to low oxygen. HIF triggers the production of different hormones, including erythropoietin (EPO), which sends a signal to your body to make more red blood cells. This helps to treat anemia and ultimately avoid the need for blood transfusions.

Your provider will determine your dose of Daprodustat based on your hemoglobin level, liver function, and other medications. The maximum daily dose is 24 mg daily.

Daprodustat is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Taking strong cytochrome P450 2C8 (CYP2C8) inhibitors like gemfibrozil
• Uncontrolled hypertension

Common side effects of Daprodustat:

• High blood pressure
• Blood clots
• Stomach pain

Serious side effects are rare with Daprodustat. Contact your healthcare provider immediately if you experience any of the following:

• Dangerously high blood pressure: headaches, changes in vision, confusion, anxiety, flushing, chest pain, trouble breathing, nausea, vomiting
• Stroke: sudden confusion, severe headache, facial drooping, weakness on one side of the body, slurred speech, trouble walking
• Heart attack: chest pain that travels to your arm or jaw, heartburn, sweating, trouble breathing, nausea, stomach pain
• Deep vein thrombosis (DVT): swollen leg, redness, pain, or warmth in the area with blood clot
• Pulmonary embolism (PE): chest pain, cough, trouble breathing, feeling lightheaded
• Serious stomach bleeding: red blood in vomit, coffee-ground vomit, black or tarry stool, blood in the urine, stomach pain
• Heart failure: difficulty breathing, sudden weight gain, wheezing, swelling, tirednessDangerously high blood pressure: headaches, changes in vision, confusion, anxiety, flushing, chest pain, trouble breathing, nausea, vomiting
• Stroke: sudden confusion, severe headache, facial drooping, weakness on one side of the body, slurred speech, trouble walking
• Heart attack: chest pain that travels to your arm or jaw, heartburn, sweating, trouble breathing, nausea, stomach pain
• Deep vein thrombosis (DVT): swollen leg, redness, pain, or warmth in the area with blood clot
• Pulmonary embolism (PE): chest pain, cough, trouble breathing, feeling lightheaded
• Serious stomach bleeding: red blood in vomit, coffee-ground vomit, black or tarry stool, blood in the urine, stomach pain
• Heart failure: difficulty breathing, sudden weight gain, wheezing, swelling, tiredness

The following medications may interact with Daprodustat:

• CYP2C8 inhibitors and inducers

Various FDA-approved generic manufacturers

Daprodustat may cause harm to your unborn baby. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment.

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