Are you tired of high medication costs? Our service offers unbeatable savings on your CUPRIMINE prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.

Manufactured by Bausch Health

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

This content is intended for US audiences only

CUPRIMINE cost saving options available to you

  • Qualified

    Rx Advantage Card

    NowPatient's Rx Advantage card is a simple & convenient way to save money on your CUPRIMINE

    You can save up to 90%

  • Available

    Canadian Prescription Savings

    Manufactured by
    Powered by
    Buy your CUPRIMINE without insurance from Canada at discounts of up to 90% using NowPatient's Canadian Prescription savings program.
  • Unavailable

    Drug Coupons

    Obtain your CUPRIMINE for as little as $0 per fill. Suitable for insured individuals only.
  • Available

    Patient Assistance Programs

    Obtain your CUPRIMINE at no cost. Suitable for insured, underinsured and uninsured individuals

    You can receive for FREE


How it works

How to Lower Your Drug Costs

  • swoosh
    View programs

    View the savings programs that are available

  • swoosh
    Select program

    Pick the program that is suitable for you

  • swoosh

    If required, complete the online qualification check

  • swoosh
    Start Saving

    Enroll & Start Saving



Why Choose Our Service?

  • black dot icon

    Comprehensive Coverage

    Our service covers a wide range of medications, ensuring you can find savings on almost any prescription.

  • emoji icon

    Easy to Use

    Our website is user-friendly, allowing you to quickly find and apply discounts.

  • check icon

    Trusted by Many

    Thousands of users trust us to help them save on their medication costs every day.


Start Saving Today!

Lower the cost of your CUPRIMINE prescription

Join the many satisfied customers who have already benefited from our prescription discount service.

CUPRIMINE Uses, Side Effects, Interactions, Warnings & Dosing



CUPRIMINE is the brand name for penicillamine and is available as an oral capsule.

What dosages is CUPRIMINE available in?

What dosages is CUPRIMINE available in?

CUPRIMINE is available as a 250 mg oral capsule.

What is CUPRIMINE used for?

What is CUPRIMINE used for?

CUPRIMINE is a chelating agent and is used for the following:

  • Wilson’s disease
  • Cystinuria
  • Severe rheumatoid arthritis (RA) when other medications haven’t worked well
How does CUPRIMINE work?

How does CUPRIMINE work?

CUPRIMINE is a chelating agent, meaning that it attaches to heavy metals in your body. It helps your body get rid of certain substances that cause Wilson’s disease and cystinuria. Wilson’s disease is a genetic condition that causes copper to build up in your liver, brain, and other organs. Penicillamine (Depen) attaches to the copper so your body can remove it through your urine. Cystinuria is a genetic condition that causes stones made of cystine (a protein) to form in your kidneys and bladder. Penicillamine (Depen) lowers the amount of cystine in your urine by attaching to it and forming a substance that your body can get rid of more easily. This lowers your risk of forming kidney stones and can help dissolve stones that are already formed. Rheumatoid arthritis (RA) is a condition where your body’s immune system attacks your joints, which causes swelling and pain. The way penicillamine (Depen) works to help treat RA isn’t known.

How do I take CUPRIMINE?

How do I take CUPRIMINE?

CUPRIMINE is dosed as follows:

  • This medication is available as tablets and capsules. Take penicillamine (Depen) on an empty stomach and separate from other foods or medications that contain certain minerals. See Pharmacist Tips for more details on how to take penicillamine (Depen)

Wilson’s disease

  • Adults: Typically, your dose will depend on how much copper is in your urine and blood. The dose is usually between 750 mg and 1,500 mg taken by mouth every day, split into two doses. If you aren’t tolerating higher doses, you might start with 250 mg per day, and then your provider can raise your dose slowly to avoid side effects

Children: Ask your child’s provider about the appropriate dose your child should take.


  • Adults: The typical dose is 1 to 4 grams taken by mouth every day, split into four doses throughout the day. You might start at a dose of 250 mg every day. Then, your provider can raise the dose slowly. This helps better control how well the medication works and avoid side effects
  • Children: The dose will depend on your child’s body weight. The typical dose is 30 mg/kg of weight taken by mouth every day, split into four doses throughout the day

Rheumatoid arthritis

  • Adults: The typical starting dose is 125 mg or 250 mg taken by mouth every day. Depending on how you respond to the medication, your provider might slowly raise your dose to a typical maintenance dose range of 500 mg to 700 mg per day. Dosages of more than 500 mg per day should be split into multiple doses throughout the day
  • Children: It isn’t known if penicillamine (Depen) works well in children with juvenile RA. Ask your child’s provider about alternative medications
Is it safe for me to take CUPRIMINE?

Is it safe for me to take CUPRIMINE?

CUPRIMINE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Except for the treatment of Wilson’s disease or certain patients with cystinuria, use of penicillamine during pregnancy is contraindicated. Although breast milk studies have not been reported in animals or humans, mothers on therapy with
penicillamine should not nurse their infants. Patients with a history of penicillamine-related aplastic anemia or agranulocytosis should not be restarted on penicillamine.
Because of its potential for causing renal damage, penicillamine should not be administered to
rheumatoid arthritis patients with a history or other evidence of renal insufficiency.

CUPRIMINE Common Side Effects

CUPRIMINE Common Side Effects

Common side effects of CUPRIMINE:

  • Stomach problems, such as loss of appetite, stomach pain, nausea, vomiting, or diarrhea
  • Total or partial loss of taste
  • Protein in urine
  • Rash
CUPRIMINE Serious Side Effects

CUPRIMINE Serious Side Effects

Serious side effects are rare with CUPRIMINE. Contact your healthcare provider immediately if you experience any of the following.

  • Low white blood cells: getting fevers, sore throat, or chills too often or if they don’t go away
  • Low platelets: bruising, bleeding
  • Kidney damage: blood in your urine
Effects of other drugs, drug classes and over-the-counter products on CUPRIMINE

Effects of other drugs, drug classes and over-the-counter products on CUPRIMINE

There are no major drug interactions listed for CUPRIMINE. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Who makes CUPRIMINE?

Who makes CUPRIMINE?

Bausch Health

Is CUPRIMINE safe in pregnancy?

Is CUPRIMINE safe in pregnancy?

CUPRIMINE can cause fetal harm when administered to a pregnant woman. Except for the treatment of Wilson’s disease or certain patients with cystinuria, use of CUPRIMINE
during pregnancy is contraindicated.


What to do if you missed your CUPRIMINE dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
dollar sign

Drug Savings Tips

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

FAQ logo

Things to know

Now Patient Data Security

Data Security

Our Commitment to You.

Find out moreNow Patient Data SecurityNow Patient Data Security

What is NowPatient

Online Pharmacy & Telehealth

NowPatient is an online pharmacy & telehealth service that is available in the US and UK. Our service is FREE and packed with useful features that can help you save money on the cost of your medications, access virtual treatments, and provide tools that can help improve your overall health.  Get started today and benefit from medication reminders, private treatment plans, NHS online pharmacy, GP appointment booking, Rx savings card, Drug Coupons, US drug savings programs, health conditions information, Drug Information, genetic testing, home test kits, BMI Risks, Type 2 Diabetes Riskspollen meter, air quality monitor, and lots more!

A laptop screen displays a dashboard with various health metrics and notifications. Widgets include drug coupons, home health testing, genetic risk, diabetes risk, BMI, pollen meter, and air quality.


To improve the lives of everyone by making high-quality care accessible and convenient

We are here to improve lives. Our service gives you access to smart features and resources that can help empower you to take control of your health and improve your health outcomes. All this, in one place, for FREE. We strive to bring a fresh perspective to managing health. NowPatient can be accessed by downloading the App or using your web browser.

Download our app today

A collage showing a map with pharmacies, a questionnaire, medication details, and a person video chatting on a screen.

Can I trust NowPatient

Meet our medical team

We are a passionate group of clinicians and medical writers covering a broad range of specialities with experience operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process

Your Questions Answered

For your peace of mind, we can answer your questions quickly

We have a comprehensive list of FAQ’s on each feature page. Alternatively, for broader questions around our service just click the button below.
Find your answers