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Coreg CR is the brand name for carvedilol and is available as an extended-release oral capsule.

Coreg CR is available as a 10 mg, 20 mg, 40 mg, and 80 mg extended-release oral capsule.

Coreg CR is a beta blocker used for high blood pressure, heart failure and to lower the risk of death from heart-related problems after a heart attack.

Coreg CR is an alpha and beta blocker medication. It lowers blood pressure by relaxing your blood vessels and slowing down your heart rate.

Coreg CR is typically taken by mouth once daily up to a maximum of 80 mg.

Coreg CR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have bronchial asthma or related bronchospastic conditions, second- or third-degree AV block, sick sinus syndrome, severe bradycardia (unless permanent pacemaker in place, are in cardiogenic shock or decompensated heart failure requiring the use of IV inotropic therapy, or have severe hepatic impairment.

Common side effects of Coreg CR include:

• Dizziness
• Orthostatic hypotension (drop in blood pressure when you stand up from sitting or lying down)
• Trouble sleeping
• Diarrhea

Serious side effects are rare with Coreg CR. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic reaction: skin rash; swelling of the face, lips, tongue, or throat; difficulty breathing
• Heart failure: trouble breathing, fast weight gain, feeling very tired, chest pain, swelling in the legs, ankles, or feet
• Bronchospasm: tightness in the chest, trouble catching your breath, difficulty breathing, wheezing, cough, dizziness, extreme tiredness

The following medications may interact with Coreg CR:

• CYP P450 2D6 enzyme inhibitors may increase and rifampin may decrease carvedilol levels
• Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia
• Cyclosporine or digoxin levels may increase
• Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the
• risk of bradycardia
• Amiodarone may increase carvedilol levels resulting in further slowing of the heart rate or cardiac conduction
• Verapamil or diltiazem-type calcium channel blockers may affect ECG and/or blood pressure
• Insulin and oral hypoglycemics action may be enhanced

GlaxoSmithKline

It is not known if Coreg CR will harm your unborn baby. If you become pregnant while receiving Coreg CR, talk to your healthcare provider.

• Carvedilol