CINRYZE
NowPatient helps you obtain your CINRYZE prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Shire US Inc.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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CINRYZE key facts
What is CINRYZE?
CINRYZE is the brand name for C1 Esterase Inhibitor (Human) that is available as an injection for IV use.
What dosages is CINRYZE available in?
CINRYZE is available as 500 IU of C1 Esterase Inhibitor (Human) for IV use.
What is CINRYZE used for?
CINRYZE is a C1 esterase inhibitor replacement and is used for prevention of hereditary angioedema (HAE) attacks in people 6 years of age and older.
How does CINRYZE work?
CINRYZE is a C1 esterase inhibitor replacement. It contains C1 esterase inhibitor, a protein in your blood that helps relieve swelling (inflammation). Hereditary angioedema (HAE) is a swelling condition caused by low levels of C1 esterase inhibitor. By raising and restoring the levels of C1 esterase inhibitor in the blood, CINRYZE helps prevent swelling attacks from happening in people with HAE.
How do I take CINRYZE?
CINRYZE is dosed as follows:
- Adults and children 12 years and older: The typical dose is 1,000 international units (IU) injected intravenously (into the vein) at a speed of 1 mL/minute (over about 10 minutes) every three or four days. The maximum dose is 2,000 IU, but not more than 80 IU/kg of body weight, every three or four days
- Children 6 to 11 years old: The typical dose is 500 IU injected intravenously at a speed of 1 mL/minute (over about 5 minutes) every three or four days. The maximum dose is 1,000 IU every three or four days
Is it safe for me to take CINRYZE?
CINRYZE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
CINRYZE Common Side Effects
Common side effects of CINRYZE:
- Headache
- Nausea
- Rash
- Vomiting
- Fever
CINRYZE Serious Side Effects
Serious side effects are rare with CINRYZE. Contact your healthcare provider immediately if you experience any of the following.
- Allergic reaction: hives, chest tightness, difficulty breathing, wheezing, fast heartbeat, swelling of the tongue or throat
- Blood clot: pain, swelling, warmth, or discoloration of the arm or leg, unexplained shortness of breath, chest pain or discomfort, unexplained fast heartbeat, numbness or weakness on one side of the body
Effects of other drugs, drug classes and over-the-counter products on CINRYZE
There are no major drug interactions listed for CINRYZE. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes CINRYZE?
Shire US Inc.
Is CINRYZE safe in pregnancy?
It is not known if CINRYZE can harm your unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my CINRYZE prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your CINRYZE prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient CINRYZE savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient CINRYZE savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for CINRYZE | Canadian Prescription Savings* for CINRYZE | CINRYZE Drug Coupon* | CINRYZE Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of CINRYZE?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for CINRYZE | Canadian Prescription Savings* for CINRYZE | CINRYZE Drug Coupon* | CINRYZE Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the CINRYZE savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the CINRYZE drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for CINRYZE, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the CINRYZE prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, CINRYZE is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed CINRYZE for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the CINRYZE prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the CINRYZE prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for CINRYZE
If you are having trouble paying for your CINRYZE medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for CINRYZE you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- CINRYZE is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers CINRYZE
- If CINRYZE is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for CINRYZE
If you are having trouble paying for your CINRYZE medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for CINRYZE you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers CINRYZE
- If CINRYZE is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for CINRYZE
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your CINRYZE treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for CINRYZE you will need to meet the following criteria:
- You must be currently insured and have coverage for CINRYZE
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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