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A single dose of Ciltacabtagene Autoleucel contains a cell suspension of 0.5-1.0×106 CARpositive viable T cells per kg body weight in one infusion bag.

Ciltacabtagene Autoleucel is a type of immunotherapy used to treat advanced multiple myeloma in adults.

Ciltacabtagene Autoleucel is a chimeric antigen receptor (CAR) T-cell therapy, or CAR-T therapy. With this treatment, your T-cells are removed from your body and sent to a lab. They are then modified to find and attack the multiple myeloma cancer cells in your body. Once this is done, the T-cells are infused back into your body to kill the cancer cells.

Once your immune cells are collected and modified, you will be given a regimen of fludarabine and cyclophosphamide. Prior to the infusion you will be pretreated with acetaminophen and an H1 antihistamine. Your providerr will then infuse Ciltacabtagene Autoleucel into the vein as a one-time infusion over 30 to 60 minutes.

Ciltacabtagene Autoleucel is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Ciltacabtagene Autoleucel:

• Low blood cell counts
• Fever
• Cytokine release syndrome
• Low immunoglobulins levels
• Low blood pressure
• Muscle pain
• Fatigue
• Infections
• Diarrhea
• Chills
• Nausea

Serious side effects are rare with ciltacabtagene autoleucelCytokine release syndrome: Fever, trouble breathing, dizziness, chills, low blood pressure, fast heartbeat, headache, tiredness
Serious nervous system problems: headache, confusion, changes in personality, depression, difficulty speaking, difficulty writing, weakness in the arms and legs, tingling in the hands and feet, tremor, slower movement, seizures
Serious infections: fever, body aches, fast heartbeat, chills
Bleeding (from low platelets): nosebleeds, blood in urine, blood in stool, unexplained bruising. Contact your healthcare provider immediately if you experience any of the following:

The following medications may interact with Carvytki:

• Some commercial HIV nucleic acid tests (NATs) may yield false-positive results in patients who have received this medication

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Carvykti