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Byetta is the brand name for exenatide and is available as a subcutaneous injection.

Byetta is available as 250 mcg/mL exenatide in:

• 5 mcg per dose, 60 doses, 1.2 mL prefilled pen
• 10 mcg per dose, 60 doses, 2.4 mL prefilled pen

Byetta is a GLP-1 receptor agonist that is used to treat type 2 diabetes, in combination with diet and exercise (adults)

Byetta is a glucagon-like peptide-1 (GLP-1) receptor agonist. It acts like GLP-1, a hormone that tells your body to release insulin after you eat. Also like GLP-1, exenatide blocks your liver from releasing sugar into your blood. These actions help control and maintain blood sugar levels in people with type 2 diabetes.

The typical dose of Byetta is 5 to 10 mcg injected under the skin twice a day. Inject within 60 minutes before the two main meals of the day, at least 6 hours apart.

Byetta is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2.

Common side effects of Byetta:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Injection-site lump
• Constipation

Serious side effects are rare with Byetta. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic reaction: rash, hives, trouble breathing, swelling of the face or throat
• Thyroid cancer: lump in the throat, pain in the neck, jaw, or ear, hoarseness, trouble swallowing or breathing
• Inflammation of the pancreas (pancreatitis): pain, swelling, or tenderness in the stomach, fever, nausea, vomiting, fast heartbeat
• Low blood sugar: headache, drowsiness, weakness, hunger, fast heart beat, dizziness, confusion, anxiety, sweating, blurred vision, slurred speech
• Serious kidney injury: nausea, vomiting, diarrhea, changes in urinary frequency, swelling in legs or ankles, tiredness, shortness of breath
• Serious bleeding problems: unusual bleeding, bleeding when you brush your teeth, easy bruising, pinpoint red spots on the skin

The following medications may interact with Byetta:

• May impact absorption of orally administered medications.
• Warfarin: Postmarketing reports with exenatide of increased international normalized ratio (INR) sometimes associated withbleeding. Monitor INR frequently until stable upon initiation  ofBYETTA therapy

AstraZeneca

Byetta may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Byetta . Talk to your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant.

• Exenatide