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Bydureon Bcise is the brand name for exenatide extended-release and is available as a subcutaneous injection.

Bydureon Bcise is available as an extended-release injectable suspension: 2 mg of exenatide in a 0.85 mL single-dose autoinjector.

Bydureon Bcise is a GLP-1 receptor agonist that is used to treat type 2 diabetes, in combination with diet and exercise (adults and children age 10 years and older) – Bydureon Bcise only.

Bydureon Bcise is a glucagon-like peptide-1 (GLP-1) receptor agonist. It acts like GLP-1, a hormone that tells your body to release insulin after you eat. Also like GLP-1, exenatide blocks your liver from releasing sugar into your blood. These actions help control and maintain blood sugar levels in people with type 2 diabetes.

The typical dose of Bydureon Bcise is 2 mg injected under the skin once a week at any time of day with or without meals.

Bydureon Bcise is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2.

Common side effects of Bydureon Bcise:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Injection-site lump
• Constipation

Serious side effects are rare with Bydureon Bcise. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic reaction: rash, hives, trouble breathing, swelling of the face or throat
• Thyroid cancer: lump in the throat, pain in the neck, jaw, or ear, hoarseness, trouble swallowing or breathing
  Inflammation of the pancreas (pancreatitis): pain, swelling, or tenderness in the stomach, fever, nausea, vomiting, fast heartbeat
• Low blood sugar: headache, drowsiness, weakness, hunger, fast heart beat, dizziness, confusion, anxiety, sweating, blurred vision, slurred speech
• Serious kidney injury: nausea, vomiting, diarrhea, changes in urinary frequency, swelling in legs or ankles, tiredness, shortness of breath
• Serious bleeding problems: unusual bleeding, bleeding when you brush your teeth, easy bruising, pinpoint red spots on the skin

The following medications may interact with Bydureon Bcise:

• May impact absorption of orally administered medications.
• Warfarin: Postmarketing reports with exenatide of increased international normalized ratio (INR) sometimes associated with bleeding. Monitor INR frequently until stable upon initiation of Bydureon Bcise therapy

AstraZeneca

Bydureon Bcise may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Bydureon Bcise. Talk to your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant.

• Exenatide Extended-Release