Used for Hypertension

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Manufactured by various FDA-approved generic manufacturers.

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bosentan Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is bosentan available in?

What dosages is bosentan available in?

bosentan is available as a 62.5 mg and 125 mg oral tablet and a 32 mg oral suspension.

What is bosentan used for?

What is bosentan used for?

  • bosentan is an endothelin receptor antagonist that is used to treat pulmonary arterial hypertension (PAH)
How does bosentan work?

How does bosentan work?

bosentan is an endothelin receptor antagonist. It works on proteins in your body that control the blood flow going to your lungs. This medication relaxes the arteries in your lung and allows more blood to flow through. As a result, your heart is able to pump better, your body gets more oxygen, and you should be able to breathe and exercise easier.

How do I take bosentan?

How do I take bosentan?

bosentan is dosed as follows:

  • Adults and children over 12 years old: Start with 62.5 mg by mouth twice daily. After 4 weeks, if you weigh over 40 kg (88 pounds), your provider might increase your dose to 125 mg by mouth twice daily
  • Children ages 3 to 12 years old: Depending on your child’s weight, they can take between 16 mg and 64 mg by mouth twice daily
Is it safe for me to take bosentan?

Is it safe for me to take bosentan?

bosentan is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Pregnancy
  • Use with Cyclosporine A
  • Use with Glyburide
  • Hypersensitivity
bosentan Common Side Effects

bosentan Common Side Effects

Common side effects of bosentan:

  • Common cold symptoms or lung infection
  • Headache
  • Swelling due to fluid buildup
  • Chest pain
  • Fainting
  • Warmth and redness in the face, neck, or chest
  • Low blood pressure
  • Sinus inflammation
bosentan Serious Side Effects

bosentan Serious Side Effects

Serious side effects are rare with bosentan. Contact your healthcare provider immediately if you experience any of the following.

  • Liver failure
  • Heart failure
  • Allergic reactions
Effects of other drugs, drug classes and over-the-counter products on bosentan

Effects of other drugs, drug classes and over-the-counter products on bosentan

  • The following medications may interact with bosentan:
  • Cytochrome P450: Coadministration of bosentan with drugs metabolized by CYP2C9 and CYP3A can increase exposure to bosentan and/or the coadministered drug
  • Hormonal contraceptives: bosentan use decreases contraceptive exposure and reduces effectiveness
Who makes bosentan?

Who makes bosentan?

Various FDA-approved generic manufacturers

Is bosentan safe in pregnancy?

Is bosentan safe in pregnancy?

Based on animal data, bosentan is likely to cause major birth defects if used during pregnancy. Must exclude pregnancy before and during treatment. To prevent pregnancy, females of reproductive potential must use two reliable forms of contraception during treatment and for one month after stopping bosentan.


What to do if you missed your bosentan dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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