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Bosentan is available as a 62.5 mg and 125 mg oral tablet and a 32 mg oral suspension.

• Bosentan is an endothelin receptor antagonist that is used to treat pulmonary arterial hypertension (PAH)

Bosentan is an endothelin receptor antagonist. It works on proteins in your body that control the blood flow going to your lungs. This medication relaxes the arteries in your lung and allows more blood to flow through. As a result, your heart is able to pump better, your body gets more oxygen, and you should be able to breathe and exercise easier.

Bosentan is dosed as follows:

• Adults and children over 12 years old: Start with 62.5 mg by mouth twice daily. After 4 weeks, if you weigh over 40 kg (88 pounds), your provider might increase your dose to 125 mg by mouth twice daily
• Children ages 3 to 12 years old: Depending on your child’s weight, they can take between 16 mg and 64 mg by mouth twice daily

Bosentan is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Pregnancy
• Use with Cyclosporine A
• Use with Glyburide
• Hypersensitivity

Common side effects of Bosentan:

• Common cold symptoms or lung infection
• Headache
• Swelling due to fluid buildup
• Chest pain
• Fainting
• Warmth and redness in the face, neck, or chest
• Low blood pressure
• Sinus inflammation

Serious side effects are rare with Bosentan. Contact your healthcare provider immediately if you experience any of the following.

• Liver failure
• Heart failure
• Allergic reactions

• The following medications may interact with Bosentan:
• Cytochrome P450: Coadministration of Bosentan with drugs metabolized by CYP2C9 and CYP3A can increase exposure to Bosentan and/or the coadministered drug
• Hormonal contraceptives: Bosentan use decreases contraceptive exposure and reduces effectiveness

Various FDA-approved generic manufacturers

Based on animal data, Bosentan is likely to cause major birth defects if used during pregnancy. Must exclude pregnancy before and during treatment. To prevent pregnancy, females of reproductive potential must use two reliable forms of contraception during treatment and for one month after stopping Bosentan.

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