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Blenrep is the brand name for belantamab mafodotin-blmf and is available as an intravenous infusion.

Blenrep is available as 70 mg of belantamab mafodotin-blmf in a single-dose vial.

Blenrep is a medication used for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least two prior lines of therapy.

Blenrep is an antibody-drug conjugate (ADC). The antibody component binds to proteins called BMCA and goes inside the cancer cells. Once there, the chemotherapy part of the medication kills the tumor cells.

Your healthcare provider will determine your dose of Blenrep based on your body weight. The usual dose is 2.5 mg/kg given intravenously once every 3 weeks.

Blenrep is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Blenrep:

• Changes in the cornea (keratopathy)
• Low platelets
• Higher liver enzymes
• Low blood cell counts
• Nausea
• Blurred vision
• Fever
• Fatigue
• Diarrhea
• Eye pain and irritation
• Upper respiratory tract infection

Serious side effects are rare with Blenrep. Contact your healthcare provider immediately if you experience any of the following:

• Serious bleeds: bruising, nose bleeds, blood in urine, blood in stool, sudden and severe headache

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

GlaxoSmithKline

Blenrep should not be taken during pregnancy as it can cause harm to your unborn baby. Females who can have children should use effective birth control while taking Blenrep and for 4 months after their last dose. Males with female partners who can have children should also use birth control such as condoms while taking this medication and for 6 months after the last dose.

• Belantamab Mafodotin-Blmf