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baricitinib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is baricitinib available in?

What dosages is baricitinib available in?

baricitinib is available as a 1 mg, 2 mg, and 4 mg oral tablet.

What is baricitinib used for?

What is baricitinib used for?

baricitinib is a JAK inhibitor and is used for the following:

  • Moderate-to-severe rheumatoid arthritis (RA) in adults
  • COVID-19 in hospitalized adults who need oxygen or support from machines to help breathe
  • Severe hair loss (alopecia areata) in adults
How does baricitinib work?

How does baricitinib work?

baricitinib is a Janus kinase (JAK) inhibitor. JAK kinases are proteins in the body that play an important role in immune signaling. When JAK kinases are active, your body experiences more inflammation. baricitinib dampens down the immune system by blocking JAK kinases.

How do I take baricitinib?

How do I take baricitinib?

baricitinib is dosed as follows:

  • Rheumatoid arthritis: The typical dose is 2 mg by mouth once daily
  • COVID-19: The typical dose is 4 mg by mouth once daily for 2 weeks or until hospital discharge, whichever comes first
  • Alopecia areata: The typical starting dose is 2 mg by mouth once daily. If needed, your provider might raise your dose to 4 mg daily

Your provider will adjust your dose based on if you’re taking a medication that interacts with baricitinib, your blood cell counts, and if you have kidney or liver problems.

Is it safe for me to take baricitinib?

Is it safe for me to take baricitinib?

baricitinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

baricitinib Common Side Effects

baricitinib Common Side Effects

Common side effects of baricitinib:

  • Raised liver enzymes
  • Infections
  • Alopecia areata:
  • Upper respiratory infection
  • Headache
  • Acne
  • High cholesterol
  • Urinary tract infection
baricitinib Serious Side Effects

baricitinib Serious Side Effects

Serious side effects are rare with baricitinib. Contact your healthcare provider immediately if you experience any of the following.

  • Stroke: sudden weakness in your body, trouble speaking, confusion, dizziness
  • Arterial thrombosis (blood clot in the heart): chest pain; short of breath; pain in the jaw, neck, or back; feeling weak or light-headed
  • Pulmonary embolism (blood clot in the lung): cough, chest pain, trouble breathing, racing heart
  • Deep vein thrombosis (blood clot in the leg): leg cramp, swelling, pain, muscle tightness
  • Severe allergic reaction: rash, trouble breathing, feeling faint, swelling of the face or throat
  • Serious infections: fever, difficulty breathing, diarrhea, weakness, cough, stomach pain, sweating, chills, burning when you urinate, urinating more often
  • Stomach tear: stomach pain, bloating, change in bowel movements, bleeding
  • Liver damage: nausea, stomach pain, yellowing of the skin or whites of the eyes
Effects of other drugs, drug classes and over-the-counter products on baricitinib

Effects of other drugs, drug classes and over-the-counter products on baricitinib

The following medications may interact with baricitinib:

  • In patients taking strong Organic Anion Transporter 3 (OAT3)
  • inhibitors (e.g., probenecid) the recommended dosage should be reduced
Who makes baricitinib?

Who makes baricitinib?

Various FDA-approved generic manufacturers

Is baricitinib safe in pregnancy?

Is baricitinib safe in pregnancy?

Based on the findings from animal reproduction studies, baricitinib may cause fetal harm during pregnancy. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Report pregnancies to Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979).


What to do if you missed your baricitinib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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