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Augtyro is the brand name for repotrectinib and is available as an oral capsule.

Augtyro is available as a 40 mg oral capsule.

Augtyro is a kinase inhibitor indicated for the treatment of adult patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC).

Augtyro works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

Augtyro is typically dosed as 160 mg orally once daily for 14 days, then increase to 160 mg twice daily, with or without food.

Augtyro is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Augtyro:

• Dizziness
• Foul or metallic taste in your mouth
• Peripheral neuropathy
• Constipation
• Shortness of breath
• Loss of coordination
• Fatigue
• Confusion
• Muscular weakness

Serious side effects are rare with Augtyro. Contact your doctor right away if you experience any of the following.

• Central nervous system (CNS) effects
• Lung problems
• Liver problems
• Muscles problems
• Increase uric acid
• Bone fractures

The following medications may interact with Augtyro:

• Strong and Moderate CYP3A Inhibitors: Avoid concomitant use
• P-gp inhibitors: Avoid concomitant use.
• Strong and Moderate CYP3A Inducers: Avoid concomitant use
• Certain CYP3A Substrates: Avoid concomitant use with CYP3A substrates, where minimal concentration changes can cause reduced efficacy
• Hormonal contraceptives: Avoid concomitant use

Bristol-Myers Squibb

Augtyro can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Augtyro.
Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start treatment with Augtyro. You should use effective non-hormonal birth control (contraception) during treatment and for 2 months after the last dose of Augtyro.
Birth control methods that contain hormones (such as birth control pills, injections or transdermal system patches)
may not work as well during treatment with Augtyro.
Talk to your healthcare provider about birth control methods that may be right for you. Males with female partners who are able to become pregnant: You should use effective birth control during treatment with Augtyro and for 4 months after the last dose.

• Repotrectinib