APLENZIN
Used for Depression
Are you tired of high medication costs? Our service offers unbeatable savings on your APLENZIN prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Valeant Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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APLENZIN key facts
What is APLENZIN?
APLENZIN is the brand name for bupropion hydrobromide and is available as an oral tablet.
What dosages is APLENZIN available in?
APLENZIN is available as a 174 mg, 348 mg, and 522 mg extended-release oral tablet.
What is APLENZIN used for?
APLENZIN is an atypical antidepressant and is used for the following:
- Depression
- Seasonal affective disorder (SAD)
How does APLENZIN work?
APLENZIN is an atypical antidepressant. It’s not fully known how the medication works but it’s thought to boost norepinephrine and dopamine levels in the brain, which can help to improve mood and depression.
How do I take APLENZIN?
APLENZIN is dosed as follows:
- Depression: The typical starting dose is 174 mg by mouth once daily. After 4 days, your provider might raise your dose to the target of 348 mg by mouth once daily
- Seasonal affective disorder (SAD): The typical starting dose is 174 mg by mouth once daily. After 1 week, your provider might raise your dose to the target of 348 mg by mouth once daily. Treatment is usually started in the autumn season, before your SAD symptoms begin and it’s continued through the winter season. Your provider will likely have you stop taking Aplenzin (bupropion hydrobromide) in the early spring
Your dose may differ if you have kidney or liver problems.
Is it safe for me to take APLENZIN?
APLENZIN is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:
- Seizure disorder or conditions that increase the risk of seizure (e.g., bulimia or anorexia nervosa, abrupt discontinuation of alcohol, benzodiazepines, antiepileptics, sedative/hypnotics, barbiturates
- MAO inhibitors: discontinue MAOI at least 2 weeks prior to bupropion use
- Known hypersensitivity to bupropion or other ingredients of APLENZIN
APLENZIN Common Side Effects
Common side effects of APLENZIN:
- Headache
- Dry mouth
- Nausea
- Trouble sleeping
- Dizziness
- Sore throat
- Constipation
- Restlessness (agitation)
APLENZIN Serious Side Effects
Serious side effects are rare with APLENZIN. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts and changes in mood or behavior
- Serious allergic reactions: itchy skin, skin rash, hives, swelling, shortness of breath, chest pain
- Severe skin reactions: painful rash, fluid-filled blisters, fever, sore throat, peeling skin
- Seizures
- Manic episodes: very high or low energy, angry or very happy, problems with sleep
- Vision problems: eye pain, changes in vision, swelling or redness in or around the eye
Effects of other drugs, drug classes and over-the-counter products on APLENZIN
The following medications may interact with APLENZIN:
- CYP2B6 inhibitors and inducers: APLENZIN is primarily metabolized by CYP2B6. Dose adjustment may be necessary if coadministered with CYP2B6 inhibitors or inducers. Inhibitors (e.g. ticlopidine and clopidogrel)
- can increase levels of bupropion. Inducers (ritonavir, lopinavir, and efavirenz) can decrease levels of bupropion
- Carbamazepine, phenobarbital, phenytoin can induce metabolism of APLENZIN and decrease exposure. Dose increase may be necessary
- Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., nortriptyline, imipramine
- desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g. haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and
- Type 1C antiarrhythmics (e.g., propafenone, flecainide). Consider dose reduction when using with bupropion.
- Drugs that lower seizure threshold: Cautious bupropion dosing
- Dopaminergic Drugs (levodopa and amantadine): CNS toxicity can occur when used concomitantly with APLENZIN
- Drug laboratory test interactions: APLENZIN can cause false-positive urine test results for amphetamines
Who makes APLENZIN?
Valeant Pharmaceuticals
Is APLENZIN safe in pregnancy?
It is not known if APLENZIN will harm your unborn baby. You and your healthcare provider will have to decide if you should take APLENZIN while you are pregnant. APLENZIN should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
Drug Savings Tips
How can NowPatient help me to lower the cost of my APLENZIN prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your APLENZIN prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient APLENZIN savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient APLENZIN savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for APLENZIN | Canadian Prescription Savings* for APLENZIN | APLENZIN Drug Coupon* | APLENZIN Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of APLENZIN?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for APLENZIN | Canadian Prescription Savings* for APLENZIN | APLENZIN Drug Coupon* | APLENZIN Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the APLENZIN savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the APLENZIN drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for APLENZIN, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the APLENZIN prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, APLENZIN is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed APLENZIN for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the APLENZIN prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the APLENZIN prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for APLENZIN
If you are having trouble paying for your APLENZIN medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for APLENZIN you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- APLENZIN is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers APLENZIN
- If APLENZIN is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for APLENZIN
If you are having trouble paying for your APLENZIN medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for APLENZIN you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers APLENZIN
- If APLENZIN is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for APLENZIN
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your APLENZIN treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for APLENZIN you will need to meet the following criteria:
- You must be currently insured and have coverage for APLENZIN
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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