Used for Depression

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Manufactured by Valeant Pharmaceuticals

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Updated on 26 Apr 2024

APLENZIN Uses, Side Effects, Interactions, Warnings & Dosing



APLENZIN is the brand name for bupropion hydrobromide and is available as an oral tablet.

What dosages is APLENZIN available in?

What dosages is APLENZIN available in?

APLENZIN is available as a 174 mg, 348 mg, and 522 mg extended-release oral tablet.

What is APLENZIN used for?

What is APLENZIN used for?

APLENZIN is an atypical antidepressant and is used for the following:

  • Depression
  • Seasonal affective disorder (SAD)
How does APLENZIN work?

How does APLENZIN work?

APLENZIN is an atypical antidepressant. It’s not fully known how the medication works but it’s thought to boost norepinephrine and dopamine levels in the brain, which can help to improve mood and depression.

How do I take APLENZIN?

How do I take APLENZIN?

APLENZIN is dosed as follows:

  • Depression: The typical starting dose is 174 mg by mouth once daily. After 4 days, your provider might raise your dose to the target of 348 mg by mouth once daily
  • Seasonal affective disorder (SAD): The typical starting dose is 174 mg by mouth once daily. After 1 week, your provider might raise your dose to the target of 348 mg by mouth once daily. Treatment is usually started in the autumn season, before your SAD symptoms begin and it’s continued through the winter season. Your provider will likely have you stop taking Aplenzin (bupropion hydrobromide) in the early spring

Your dose may differ if you have kidney or liver problems.

Is it safe for me to take APLENZIN?

Is it safe for me to take APLENZIN?

APLENZIN is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:

  • Seizure disorder or conditions that increase the risk of seizure (e.g., bulimia or anorexia nervosa, abrupt discontinuation of alcohol, benzodiazepines, antiepileptics, sedative/hypnotics, barbiturates
  • MAO inhibitors: discontinue MAOI at least 2 weeks prior to bupropion use
  • Known hypersensitivity to bupropion or other ingredients of APLENZIN
APLENZIN Common Side Effects

APLENZIN Common Side Effects

Common side effects of APLENZIN:

  • Headache
  • Dry mouth
  • Nausea
  • Trouble sleeping
  • Dizziness
  • Sore throat
  • Constipation
  • Restlessness (agitation)
APLENZIN Serious Side Effects

APLENZIN Serious Side Effects

Serious side effects are rare with APLENZIN. Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts and changes in mood or behavior
  • Serious allergic reactions: itchy skin, skin rash, hives, swelling, shortness of breath, chest pain
  • Severe skin reactions: painful rash, fluid-filled blisters, fever, sore throat, peeling skin
  • Seizures
  • Manic episodes: very high or low energy, angry or very happy, problems with sleep
  • Vision problems: eye pain, changes in vision, swelling or redness in or around the eye
Effects of other drugs, drug classes and over-the-counter products on APLENZIN

Effects of other drugs, drug classes and over-the-counter products on APLENZIN

The following medications may interact with APLENZIN:

  • CYP2B6 inhibitors and inducers: APLENZIN is primarily metabolized by CYP2B6. Dose adjustment may be necessary if coadministered with CYP2B6 inhibitors or inducers. Inhibitors (e.g. ticlopidine and clopidogrel)
  • can increase levels of bupropion. Inducers (ritonavir, lopinavir, and efavirenz) can decrease levels of bupropion
  • Carbamazepine, phenobarbital, phenytoin can induce metabolism of APLENZIN and decrease exposure. Dose increase may be necessary
  • Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., nortriptyline, imipramine
  • desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g. haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and
  • Type 1C antiarrhythmics (e.g., propafenone, flecainide). Consider dose reduction when using with bupropion.
  • Drugs that lower seizure threshold: Cautious bupropion dosing
  • Dopaminergic Drugs (levodopa and amantadine): CNS toxicity can occur when used concomitantly with APLENZIN
  • Drug laboratory test interactions: APLENZIN can cause false-positive urine test results for amphetamines
Who makes APLENZIN?

Who makes APLENZIN?

Valeant Pharmaceuticals

Is APLENZIN safe in pregnancy?

Is APLENZIN safe in pregnancy?

It is not known if APLENZIN will harm your unborn baby. You and your healthcare provider will have to decide if you should take APLENZIN while you are pregnant. APLENZIN should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


What to do if you missed your APLENZIN dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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