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Amjevita is the brand name for adalimumab-atto subcutaneous injection.

Amjevita is available as a 80 mg/0.8 mL, 40 mg/0.8 mL,
40 mg/0.4 mL, 20 mg/0.4 mL, 20 mg/0.2 mL, or 10 mg/0.2 mL injection.

Amjevita is a biologic DMARD that is used to treat:

• Rheumatoid arthritis (RA) – adults only
• Juvenile idiopathic arthritis (JIA) – people age 2 and older
• Psoriatic arthritis (PsA) – adults only
• Ankylosing spondylitis (AS) – adults only
• Crohn’s disease (CD) – people age 6 and older
• Ulcerative colitis (UC) – adults only
• Plaque psoriasis – adults only
• Hidradenitis suppurativa – adults only

Amjevita is a biologic disease-modifying antirheumatic drug (DMARD). It works by blocking tumor necrosis factor (TNF), a protein in your body that plays a role in inflammation. By blocking TNF, it lowers inflammation to relieve symptoms in different parts of your body.

Amjevita is dosed as follows:

Adults

• Rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: The typical starting dose is 40 mg injected under the skin every other week
• Crohn’s disease and ulcerative colitis: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every other week starting Day 29 (2 weeks later)
• Plaque psoriasis: The typical dose is 80 mg injected under the skin on Day 1, followed by 40 mg every other week starting 1 week after the first dose
• Hidradenitis suppurativa: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every week OR 80 mg every other week starting Day 29

Children

• Juvenile idiopathic arthritis and Crohn’s disease: The dose will be based on your child’s body weight. Typically it will be injected under the skin once every other week

Amjevita is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Amjevita:

• Injection site reaction
• Upper respiratory tract infection
• Headache
• Rash
• Sinus inflammation
• Accidental injury
• Nausea
• Urinary tract infection (UTI) or bladder infection

Serious side effects are rare with Amjevita. Contact your healthcare provider immediately if you experience any of the following.

• Serious infection: fever, cough, weight loss, muscle aches, dark urine, chills, vomiting
• Low blood cell counts: fever that doesn’t go away, easy bruising or bleeding, pale skin
• Severe allergic reaction: rash, trouble breathing, swelling of your face, eyes, lips, or mouth, hives
• Heart failure: shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, tiredness, sudden weight gain
• Liver problems: feeling tired, vomiting, yellow skin or whites of the eyes, stomach pain

The following medications may interact with Amjevita:

• Abatacept: Increased risk of serious infection
• Anakinra: Increased risk of serious infection
• Live vaccines: Avoid use with Amjevita

Amgen Inc.

It is not known if Amjevita can harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.

• Adalimumab