AKEEGA
Used for Cancer
Are you tired of high medication costs? Our service offers unbeatable savings on your AKEEGA prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Janssen Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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AKEEGA key facts
What is AKEEGA?
AKEEGA is the brand name for for niraparib and abiraterone acetate and is available as an oral tablet.
What dosages is AKEEGA available in?
AKEEGA is available as an oral tablet that contains 50 mg niraparib/500 mg abiraterone acetate or 100 mg niraparib/500 mg abiraterone acetate.
What is AKEEGA used for?
- AKEEGA is a combination of niraparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, and abiraterone acetate, a CYP17 inhibitor indicated with prednisone for the treatment of adult patients with deleterious or suspected deleterious BRCAmutated (BRCAm) metastatic castration-resistant prostate cancer (mCRPC)
How does AKEEGA work?
AKEEGA contains two active substances: niraparib and abiraterone acetate. Niraparib blocks the action of enzymes called PARP-1 and PARP-2, which help to repair damaged DNA in cells when the cells divide to make new cells. The blocking of the PARP enzymes prevents cancer cells from repairing damaged DNA, and, as a result, the cancer cells die.
The other active substance, abiraterone acetate, stops the body producing testosterone by blocking an enzyme called CYP17 found in the testes and elsewhere in the body. Because the cancer needs a supply of testosterone to survive and grow, abiraterone acetate helps slow the growth of the prostate cancer.
How do I take AKEEGA?
- AKEEGA is typically taken as 200 mg niraparib/1,000 mg abiraterone acetate orally once daily in combination with 10 mg prednisone daily until disease progression or unacceptable toxicity
- Patients receiving AKEEGA should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy
- Take AKEEGA on an empty stomach. Do not eat food two hours before and one hour after taking AKEEGA
Is it safe for me to take AKEEGA?
AKEEGA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
AKEEGA Common Side Effects
Common side effects of AKEEGA:
- Decreased hemoglobin, lymphocytes, neutrophils, and white blood cells
- Musculoskeletal pain
- Fatigue
- Decreased platelets
- Constipation
- Hypertension
- Nausea
- Increased creatinine
- Increased potassium
- Edema
- Shortness of breath
- Decreased appetite
- Vomiting
- Dizziness
- Headache
- Abdominal pain
- Urinary tract infection
- Cough
- Insomnia
AKEEGA Serious Side Effects
Serious side effects are rare with AKEEGA. Some examples include:
- High blood pressure (hypertension), low blood potassium levels (hypokalemia), fluid retention (edema), and irregular heartbeats.
- Adrenal problems
- Severe liver problems
- Liver problems
- Low blood sugarIncreased risk of bone fracture and deathPosterior Reversible Encephalopathy Syndrome (PRES)
Effects of other drugs, drug classes and over-the-counter products on AKEEGA
The following medications may interact with AKEEGA:
- Strong CYP3A4 Inducers: Avoid coadministration
- CYP2D6 Substrates: Avoid coadministration of AKEEGA with CYP2D6 substrates for which minimal changes in concentration may lead to serious toxicities
- If alternative treatments cannot be used, consider a dose reduction of the concomitant CYP2D6 substrate
Who makes AKEEGA?
Janssen Pharmaceuticals
Is AKEEGA safe in pregnancy?
The safety and efficacy of AKEEGA have not been established in females. Based on findings from animal studies and the mechanism of action, AKEEGA can cause fetal harm and potential loss of pregnancy.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my AKEEGA prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your AKEEGA prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient AKEEGA savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient AKEEGA savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for AKEEGA | Canadian Prescription Savings* for AKEEGA | AKEEGA Drug Coupon* | AKEEGA Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of AKEEGA?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for AKEEGA | Canadian Prescription Savings* for AKEEGA | AKEEGA Drug Coupon* | AKEEGA Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the AKEEGA savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the AKEEGA drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for AKEEGA, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the AKEEGA prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, AKEEGA is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed AKEEGA for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the AKEEGA prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the AKEEGA prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for AKEEGA
If you are having trouble paying for your AKEEGA medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for AKEEGA you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- AKEEGA is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers AKEEGA
- If AKEEGA is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for AKEEGA
If you are having trouble paying for your AKEEGA medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for AKEEGA you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers AKEEGA
- If AKEEGA is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for AKEEGA
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your AKEEGA treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for AKEEGA you will need to meet the following criteria:
- You must be currently insured and have coverage for AKEEGA
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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