AKEEGA
Used for Cancer
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Manufactured by Janssen Pharmaceuticals
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AKEEGA Uses, Side Effects, Interactions, Warnings & Dosing
What is AKEEGA?
AKEEGA is the brand name for for niraparib and abiraterone acetate and is available as an oral tablet.
What dosages is AKEEGA available in?
AKEEGA is available as an oral tablet that contains 50 mg niraparib/500 mg abiraterone acetate or 100 mg niraparib/500 mg abiraterone acetate.
What is AKEEGA used for?
- AKEEGA is a combination of niraparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, and abiraterone acetate, a CYP17 inhibitor indicated with prednisone for the treatment of adult patients with deleterious or suspected deleterious BRCAmutated (BRCAm) metastatic castration-resistant prostate cancer (mCRPC)
How does AKEEGA work?
AKEEGA contains two active substances: niraparib and abiraterone acetate. Niraparib blocks the action of enzymes called PARP-1 and PARP-2, which help to repair damaged DNA in cells when the cells divide to make new cells. The blocking of the PARP enzymes prevents cancer cells from repairing damaged DNA, and, as a result, the cancer cells die.
The other active substance, abiraterone acetate, stops the body producing testosterone by blocking an enzyme called CYP17 found in the testes and elsewhere in the body. Because the cancer needs a supply of testosterone to survive and grow, abiraterone acetate helps slow the growth of the prostate cancer.
How do I take AKEEGA?
- AKEEGA is typically taken as 200 mg niraparib/1,000 mg abiraterone acetate orally once daily in combination with 10 mg prednisone daily until disease progression or unacceptable toxicity
- Patients receiving AKEEGA should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy
- Take AKEEGA on an empty stomach. Do not eat food two hours before and one hour after taking AKEEGA
Is it safe for me to take AKEEGA?
AKEEGA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
AKEEGA Common Side Effects
Common side effects of AKEEGA:
- Decreased hemoglobin, lymphocytes, neutrophils, and white blood cells
- Musculoskeletal pain
- Fatigue
- Decreased platelets
- Constipation
- Hypertension
- Nausea
- Increased creatinine
- Increased potassium
- Edema
- Shortness of breath
- Decreased appetite
- Vomiting
- Dizziness
- Headache
- Abdominal pain
- Urinary tract infection
- Cough
- Insomnia
AKEEGA Serious Side Effects
Serious side effects are rare with AKEEGA. Some examples include:
- High blood pressure (hypertension), low blood potassium levels (hypokalemia), fluid retention (edema), and irregular heartbeats.
- Adrenal problems
- Severe liver problems
- Liver problems
- Low blood sugarIncreased risk of bone fracture and deathPosterior Reversible Encephalopathy Syndrome (PRES)
Effects of other drugs, drug classes and over-the-counter products on AKEEGA
The following medications may interact with AKEEGA:
- Strong CYP3A4 Inducers: Avoid coadministration
- CYP2D6 Substrates: Avoid coadministration of AKEEGA with CYP2D6 substrates for which minimal changes in concentration may lead to serious toxicities
- If alternative treatments cannot be used, consider a dose reduction of the concomitant CYP2D6 substrate
Who makes AKEEGA?
Janssen Pharmaceuticals
Is AKEEGA safe in pregnancy?
The safety and efficacy of AKEEGA have not been established in females. Based on findings from animal studies and the mechanism of action, AKEEGA can cause fetal harm and potential loss of pregnancy.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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