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Manufactured by various FDA-approved generic manufacturers.

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

afatinib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is afatinib available in?

What dosages is afatinib available in?

afatinib is available as a 20 mg, 30 mg, and 40 mg oral tablet.

What is afatinib used for?

What is afatinib used for?

afatinib is a kinase inhibitor and is used for the following:

  • Non-small cell lung cancer (NSCLC) in people with:
  • Metastatic NSCLC that have non-resistant mutations in the EGFR gene
  • Metastatic squamous NSCLC that’ve gotten worse after receiving platinum therapy
How does afatinib work?

How does afatinib work?

afatinib is a kinase inhibitor that works by attaching to these EGFR proteins. When it does, the proteins can’t continue to send signals for cancer cells to grow. This means cancer cells can’t grow and spread as well.

How do I take afatinib?

How do I take afatinib?

  • afatinib is typically taken as 40 mg taken by mouth once daily
  • Your dose might be different if you’re also taking medications that can interact with afatinib or have severe kidney problems
Is it safe for me to take afatinib?

Is it safe for me to take afatinib?

afatinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

afatinib Common Side Effects

afatinib Common Side Effects

Common side effects of afatinib:

  • Diarrhea
  • Rash or acne-like bumps on the skin
  • Painful sores in the mouth or throat
  • Nail infection
  • Higher liver enzyme levels
  • Kidneys not working as well
  • Low white blood cell counts
  • Dry skin
  • Low potassium levels
  • Loss of appetite
  • Nausea
  • Itchy skin
afatinib Serious Side Effects

afatinib Serious Side Effects

Serious side effects are rare with afatinib. Contact your healthcare provider immediately if you experience any of the following.

  • Serious skin reactions: painful rash, blisters, peeling skin
  • Lung problems: cough, fever, trouble breathing, shortness of breath, chest – pain
  • Serious liver problems: tiredness, loss of appetite, nausea or vomiting, dark urine, right-side stomach pain, easy bruising or bleeding, or yellowing of the eyes or skin
  • Tearing of the stomach or intestines: fever, chills, severe stomach pain, bloated stomach, nausea, vomiting
  • Severe diarrhea
Effects of other drugs, drug classes and over-the-counter products on afatinib

Effects of other drugs, drug classes and over-the-counter products on afatinib

The following medications may interact with afatinib:

  • Co-administration of P-gp inhibitors can increase afatinib exposure. Reduce afatinib by 10 mg per day if not tolerated. Co-administration of chronic
  • P-gp inducers orally can decrease afatinib exposure. Increase afatinib by 10 mg per day as tolerated
Who makes afatinib?

Who makes afatinib?

Various FDA-approved generic manufacturers

Is afatinib safe in pregnancy?

Is afatinib safe in pregnancy?

Based on findings from animal studies and its mechanism of action, afatinib can cause fetal harm when administered to a pregnant woman. If you can become pregnant, use effective contraception during treatment, and for at least 2
weeks after the last dose of afatinib.


What to do if you missed your afatinib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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