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Adynovate is the brand name for antihemophilic factor and is available as an intravenous injection.

Adynovate is available as a lyophilized powder in single-dose vials containing nominally (approximately) 250, 500, 750, 1000, 1500, 2000, or 3000 international units.

Adynovate is indicated in adult and pediatric patients with hemophilia A (congenital factor VIII deficiency) for:

• On-demand treatment and control of bleeding episodes.
• Perioperative management.
• Routine prophylaxis to reduce the frequency of bleeding episodes.

Adynovate is a PEGylated form of recombinant antihemophilic factor. It replaces special blood-clotting proteins called factor VIII (FVIII) due to hemophilia A in people who don’t naturally have it. This helps treat or prevent bleeding episodes.

Adynovate is typically dosed as follows:

• For on-demand treatment and control of bleeding episodes and perioperative management, you dose will be based on your weight and estimated need.
• For routine prophylaxis, administer 40-50 IU/kg body weight twice weekly in adults and adolescents (12 years and older). For children <12 years old,
• Administer 55 IU/kg twice weekly with
• A maximum of 70 IU/kg.
• Your dose and dosing intervals will be adjusted based on your clinical response.

Adynovate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have had a prior anaphylactic reaction to Adynovate, the parent molecule (Advate), mouse or hamster protein, or excipients of Adynovate.

Common side effects of Adynovate:

• Cough
• Headache
• Diarrhea
• Vomiting
• Rash
• Nausea
• Dizziness

Serious side effects are rare with Adynovate. Contact your healthcare provider immediately if you experience any of the following:

• Serious allergic reaction (anaphylaxis): difficulty breathing, hives, itching, fast heartbeat, nausea, stomach pain, dizziness, lightheadedness, swelling in the face or tongue
• Development of antibodies against FVIII

There are no major drug interactions listed for Adynovate. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Takeda Pharmaceuticals

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Antihemophilic Factor