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Levonorgestrel-Releasing Intrauterine System is available as intrauterine system consisting of a T-shaped polyethylene frame with a steroid reservoir containing 13.5 mg levonorgestrel.

Levonorgestrel-Releasing Intrauterine System is a progestin that is used to prevent pregnancy for up to 3 years.

Levonorgestrel-Releasing Intrauterine System is a small device placed in the uterus that slowly releases a progestin hormone called levonorgestrel. This hormone prevents pregnancy by stopping your ovaries from releasing an egg. Levonorgestrel also makes it difficult for sperm to reach the egg and for a fertilized egg to implant in the uterus.

Levonorgestrel-Releasing Intrauterine System will need to be placed inside your uterus by your provider at their office. Once placed, it can prevent pregnancy for 3 years.

Levonorgestrel-Releasing Intrauterine System is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Pregnancy or suspicion of pregnancy
• Use as emergency contraception
• Certain abnormal uterine anatomy
• Acute pelvic inflammatory disease (PID) or a history of PID
• Postpartum endometritis or infected abortion in the past 3 months
• Uterine or cervical cancer
• Breast cancer or other progestin-sensitive cancer
• Uterine bleeding without a known cause
• Untreated inflammation of the cervix or vagina, or other lower genital tract infections
• Liver disease or liver tumor
• A previous intrauterine device (IUD) that hasn’t been removed

Common side effects of Levonorgestrel-Releasing Intrauterine System:

• Vaginal inflammation or irritation
• Acne
• Stomach pain
• Ovarian cyst
• Headache
• Menstrual cramps
• Heavier menstrual bleeding
• Breast pain or discomfort
• Nausea

Serious side effects are rare with Levonorgestrel-Releasing Intrauterine System. Contact your healthcare provider immediately if you experience any of the following.

• Ectopic pregnancy: severe, unexplainable pelvic pain along with unusual vaginal bleeding
• Severe infection: fever, chills, confusion, fatigue

• No drug-drug interaction studies have been conducted with Levonorgestrel-Releasing Intrauterine System. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Various FDA-approved generic manufacturers

The use of Levonorgestrel-Releasing Intrauterine System is contraindicated in pregnancy or with a suspected pregnancy and Levonorgestrel-Releasing Intrauterine System may cause adverse pregnancy outcomes. If you become pregnant with Levonorgestrel-Releasing Intrauterine System in place, the likelihood of ectopic pregnancy is increased and there is an increased risk of miscarriage, sepsis, premature labor, and premature delivery. Remove Levonorgestrel-Releasing Intrauterine System, if possible, if pregnancy occurs. If Levonorgestrel-Releasing Intrauterine System cannot be removed, follow the pregnancy closely.

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