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Sirolimus is available as a 0.5 mg, 1 mg, and 2 mg oral tablet and a 1 mg/ml oral solution.

Sirolimus is an immunosuppressant that is used to treat:
Prevention of kidney transplant rejection Treatment of lymphangioleiomyomatosis (LAM)

Sirolimus is an immunosuppressant that lowers the activity of your immune system. You need a suppressed (lowered) immune system after receiving a transplant so your body doesn’t reject the new kidney.

Sirolimus is typically taken as 6 mg or 15 mg by mouth on the day after your transplant, followed by 2 mg or 5 mg by mouth every day. For lymphangioleiomyomatosis, the typical starting dose is 2 mg by mouth every day. Your provider will likely measure the level of medication in your blood after a few weeks and will adjust your dose accordingly.

Sirolimus is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Sirolimus:

• Swelling in arms and legs
• More cholesterol and fat in the blood
• High blood pressure
• Change in kidney labs
• Constipation
• Headache
• Pain
• Stomach pain
• Urinary tract infection

Serious side effects are rare with Sirolimus. Contact your healthcare provider immediately if you experience any of the following.

• Infection: fever, chills, fatigue, muscle aches
• Serious lung problems (interstitial lung disease): breathing problems, chest pain, cough, tiredness
• Serious allergic reaction: trouble breathing, swelling of the face, tightening of the throat, rash, hives, welts, peeling or blistering skin

The following medications may interact with Sirolimus:

• Avoid concomitant use with strong CYP3A4/P-gp inducers or strong CYP3A4/P-gp inhibitors that decrease or increase Sirolimus
• concentrations
• See full prescribing information for complete list of clinically significant drug interactions

Various FDA-approved generic manufacturers

Sirolimus should be used during pregnancy only if the potential benefit outweighs the potential risk to the
embryo/fetus.

• Rapamune
• Rapamune Oral Solution