Sirolimus Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Sirolimus
    Generic for Rapamune
    30 tablets $42.9 USD
    Save $203.70
  3. Sirolimus
    Generic for Rapamune
    40 tablets $57 USD
    Save $271.80
  4. Sirolimus
    Generic for Rapamune
    75 tablets $105 USD
    Save $511.50
  5. Sirolimus
    Generic for Rapamune Oral Solution
    60mL solutions $228.08 USD
    Save $852.35
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Do you need a prescription for sirolimus?

Yes, sirolimus is only available with a valid physician Rx.

How much is sirolimus without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase sirolimus, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for sirolimus in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a sirolimus savings card?

Yes. Save up to 90% on your sirolimus with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a sirolimus coupon provider in the US?

No. Now Patient does not provide sirolimus coupons or FREE sirolimus samples.

Do you accept commercial, Medicare or Medicaid coverage for sirolimus in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much sirolimus?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using sirolimus. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much sirolimus. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic sirolimus?

US brand name of sirolimus and manufacturer

Sirolimus is available in the US under the brand name Rapamune. It is manufactured by Pfizer Inc.

UK brand name of sirolimus and manufacturer

Sirolimus is available in the UK under the brand name Rapamune. It is also manufactured by Pfizer Inc.

Is sirolimus available in the UK on the NHS?

Yes, sirolimus is available on the NHS in the UK. It can be prescribed by healthcare professionals for eligible patients.

Prescription requirement for sirolimus

Sirolimus is a prescription medication and requires a prescription from a healthcare provider.

FDA approval of sirolimus

Sirolimus has received FDA (Food and Drug Administration) approval for various indications, including the prevention of organ rejection in renal transplant patients aged 13 years and older, and the treatment of lymphangioleiomyomatosis (LAM), a rare lung disease.

Active ingredient of sirolimus and mechanism of action

The active ingredient in sirolimus is sirolimus itself. It belongs to a class of medications known as immunosuppressants. Sirolimus is classed as a mTOR inhibitor. It works by inhibiting the activity of a protein called mammalian target of rapamycin (mTOR), which plays a crucial role in the regulation of cell growth and proliferation. By inhibiting mTOR, sirolimus helps to suppress the immune system and prevent organ transplant rejection.

Uses of sirolimus

Sirolimus is primarily used for the following purposes:

  • Prevention of transplanted organ rejection in kidney transplant patients aged 13 years and older
  • Treatment of lymphangioleiomyomatosis (LAM), a rare lung disease

Forms of sirolimus

Sirolimus is available in the form of oral tablets and an oral solution. The specific form and strength will depend on the prescribed dosage and formulation.

Dosage of sirolimus

The dosage of sirolimus will vary depending on the specific indication, individual patient factors, and response to therapy. It is important to follow the dosage instructions provided by your healthcare provider. Sirolimus is normally used in combination with corticosteroids and cyclosporine.

Precautions and warnings for sirolimus

  • It is important to inform your healthcare provider about any history of liver or kidney problems, as well as any other medical conditions or medications you are taking
  • Sirolimus is not recommended for the prevention of lung transplant or liver transplant rejection
  • Sirolimus may increase your risk of developing lymphoma or skin cancer
  • Sirolimus may cause certain side effects, including but not limited to mouth sores, diarrhea, high cholesterol levels, and increased blood sugar levels. Contact your healthcare provider if you experience any concerning or persistent side effects
  • Avoid grapefruit or grapefruit juice while using sirolimus
  • Sirolimus is not recommended for use if you are pregnant. Use birth control to prevent pregnancy when using sirolimus
  • Sirolimus may pass into breast milk. Speak to your doctor before breast-feeding

Side effects of sirolimus

In clinical trials common side effects of sirolimus may include:

  • Infections
  • Mouth sores
  • Constipation
  • Diarrhea
  • High cholesterol levels
  • Increased blood sugar levels
  • Sore throat

Get medical help right away if you have any serious side effects such as an allergic reaction. Symptoms include hives, trouble breathing, shortness of breath, chest pain, swelling of the face, tongue or throat, skin rash, and severe skin reactions. Promptly report any adverse effects to a healthcare professional for medical advice.

Interactions with other drugs

Sirolimus may interact with certain medications, including other immunosuppressants, angiotensin-converting enzyme inhibitors such as captopril and enalapril, antifungals such as fluconazole, itraconazole, ketoconazole, and voriconazole, clarithromycin, diltiazem, erythromycin, HIV protease inhibitors such as ritonavir, medications for cholesterol, medications for seizures such as carbamazepine, and phenytoin, metoclopramide, St. John’s wort, rifabutin, rifampin, verapamil, and live vaccines. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medication, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to sirolimus 

Other medications, similar to sirolimus include tacrolimus.


  • MedlinePlus. Sirolimus
  • Drugs.com. Sirolimus
Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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