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Norethindrone is available as a 5 mg oral tablet.

Norethindrone is a progestin that is used to treat amenorrhea (ack of menstrual periods) or abnormal bleeding from the uterus due to hormonal imbalance, and endometriosis.

Norethindrone is a progestin, which is a synthetic form of the natural sex hormone progesterone. It regulates the lining of your uterus (endometrium), which then helps manage your period and ease endometriosis-related pain.

Norethindrone is typically taken by mouth once daily. You may take it for as few as 5 to 10 days or long-term, depending on the condition being treated.

Norethindrone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you have any of the following:

• Known or suspected pregnancy.
• Undiagnosed vaginal bleeding
• Known, suspected or history of cancer of the breast
• Active deep vein thrombosis, pulmonary embolism or history of these conditions
• Active or recent (e.g., within the past year) arterial thromboembolic disease (e.g., stroke, myocardial infarction)
• Impaired liver function or liver disease

Common side effects of Norethindrone include:

• Breakthrough bleeding or spotting
• Change in menstrual flow
• Lack of periods
• Headache or migraine
• Breast enlargement
• Breast tenderness
• Nausea
• Vomiting
• Stomach cramps or bloating
• Patches of darkened skin (melasma or chloasma)
• Acne
• Hair loss
• Yellowing of the skin or whites of eyes (jaundice)
• Trouble sleeping (insomnia)
• Changes in vision

Serious side effects are rare with Norethindrone. Contact your healthcare provider immediately if you experience any of the following.

• Blood clots: leg swelling, leg pain, skin that’s warm to the touch, trouble breathing
• Heart attack: chest pain, arm pain, cold sweat, shortness of breath
• Stroke: facial droop, weakness on one side of the body, confusion, sudden, severe headache, trouble speaking, walking, or talking

• There are no major drug interactions listed for Norethindrone. However, you should always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Various FDA-approved generic manufacturers

Norethindrone is contraindicated during pregnancy as it may cause fetal harm when administered to pregnant women.

• Aygestin
• Hailey FE
• Junel
• Loestrin FE
• Nortrel
• Ortho Micronor