NitrofurantoinPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Nitrofurantoin Macrocrystals
    Generic for Macrodantin
    30 capsules $10.8 USD
    Save $69.60
  3. Nitrofurantoin Mono/Macro
    Generic for Macrobid
    30 capsules $10.2 USD
    Save $77.70
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Do you need a prescription for nitrofurantoin?

Yes, nitrofurantoin is only available with a valid physician Rx.

How much is nitrofurantoin without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase nitrofurantoin, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for nitrofurantoin in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a nitrofurantoin savings card?

Yes. Save up to 90% on your nitrofurantoin with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a nitrofurantoin coupon provider in the US?

No. Now Patient does not provide nitrofurantoin coupons or FREE nitrofurantoin samples.

Do you accept commercial, Medicare or Medicaid coverage for nitrofurantoin in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much nitrofurantoin?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using nitrofurantoin. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much nitrofurantoin. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of nitrofurantoin and manufacturer

Nitrofurantoin is available in the US under various brand names, including Macrobid, Macrodantin, and Furadantin. The specific manufacturers of these brands may vary.

UK brand name of nitrofurantoin and manufacturer

Nitrofurantoin is available in the UK under the brand names MacroBID and Macrodantin. MacroBID is manufactured by Macleods Pharma UK Limited, and Macrodantin is manufactured by Mylan.

Prescription requirement for nitrofurantoin

Nitrofurantoin is a prescription medication in both the US and the UK. It is not available over the counter and requires a prescription from a healthcare provider.

FDA approval of nitrofurantoin

Nitrofurantoin has received FDA approval for the treatment and prevention of urinary tract infections caused by susceptible bacteria.

Is nitrofurantoin available in the UK on NHS?

Nitrofurantoin is available on the NHS in the UK with a prescription from a healthcare provider. The availability and specific prescribing guidelines may vary, so it is recommended to consult with a healthcare provider or pharmacist for more information.

Mechanism of action

Nitrofurantoin is an antibacterial that works by interfering with the bacterial enzymes involved in the synthesis of bacterial DNA, RNA, and proteins. This inhibits the growth and replication of susceptible bacteria, thereby treating and preventing urinary tract infections.

Uses of nitrofurantoin

Nitrofurantoin is an antimicrobial primarily used for the treatment and prophylaxis of urinary tract infections (UTIs), including cystitis, caused by susceptible bacteria. It is effective against many common urinary tract pathogens, including Escherichia coli (E. coli) Enterococcus faecalis, Staphylococcus aureus, and certain strains of Klebsiella and Enterobacter species.

Dosage of nitrofurantoin

The dosage of nitrofurantoin will depend on the specific indication, severity of the infection, and individual patient factors. It is important to follow the dosage instructions and medical advice provided by your healthcare provider and to complete the full course of treatment, even if symptoms improve.

Contraindications and warnings for nitrofurantoin

  • Inform your healthcare provider about any known allergies or sensitivities to medications, especially nitrofurantoin
  • It is important to stay well hydrated while taking nitrofurantoin to ensure proper urinary output
  • You are recommended not to breastfeed an infant younger than 1 month old while taking this medication. Nitrofurantoin may pass into breast milk
  • Speak to your doctor if you have had kidney disease, jaundice, or other liver problems while taking nitrofurantoin. You may have an increased risk of susceptibility to renal or hepatic toxicity
  • Tell your doctor if you have anemia, diabetes, nerve damage, vitamin B deficiency, or glucose-6-phosphate dehydrogenase deficiency (G-6-PD deficiency)

Side effects of nitrofurantoin

Common side effects of nitrofurantoin may include gastrointestinal upset (nausea, vomiting, diarrhea), headache, dizziness, and rash. These side effects are usually mild and temporary.

Get medical help right away if you have serious side effects such as peripheral neuropathy, pulmonary toxicity, hepatotoxicity (liver problems such as nausea, upper stomach pain, fatigue, loss of appetite, dark urine, or jaundice), or an allergic reaction to nitrofurantoin. Symptoms may include hives, chest pain, shortness of breath, trouble breathing, and joint or muscle pain.

Interactions with other drugs

Nitrofurantoin may interact with certain medications, including antacids containing magnesium trisilicate, certain anticoagulants, and drugs that affect liver enzyme activity. It is important to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs, supplements, and herbal products, to avoid any adverse events and potential drug interactions.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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