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Fluticasone/Salmeterol is available as an inhaler containing a combination of fluticasone propionate (100 mcg, 250 mcg, or 500 mcg) and salmeterol (50 mcg).

Fluticasone/Salmeterol is a combination of fluticasone and salmeterol that work together to help treat asthma and COPD symptoms.

Fluticasone/Salmeterol contains fluticasone, which is an inhaled corticosteroid that is thought to work directly in your lungs to lower inflammation and swelling, thus making it easier for you to breathe. It also contains salmeterol, which is a long-acting beta agonist that works by relaxing the muscles in your lungs to open up your airways, making it easier to breathe.

Fluticasone/Salmeterol is typically given as 1 inhalation by mouth twice daily.

Fluticasone/Salmeterol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. It should not be used to treat an asthma attack or if you are allergic to milk proteins.

Common side effects of Fluticasone/Salmeterol include:

• Upper respiratory infection
• Sore throat
• Headache
• Bronchitis
• Cough
• Nausea and vomiting
• Hoarseness

Serious side effects are rare with Fluticasone/Salmeterol. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reaction: hives, swelling of your face, lips, or tongue, difficulty breathing
• Sudden narrowing of your airways: difficulty breathing, wheezing, chest pain or tightness, cough
• Heart problems: dizziness, fatigue, tremor, nausea, rapid heartbeat, weakness, or difficulty sleeping

The following medications may interact with Fluticasone/Salmeterol:

• beta-blockers may decrease effectiveness of salmeterol and produce severe bronchospasm
• Monoamine oxidase (MAO) inhibitors and tricyclic antidepressants may potentiate effect of salmeterol on the cardiovascular system
• Strong cytochrome P450 3A4 inhibitors such as ritonavir, ketoconazole can increse the risk of cardiovascular effects. diuretics, or non-potassium sparing diuretics may potentiate hypokalemia or ECG changes

Various FDA-approved generic manufacturers

Fluticasone/Salmeterol has not been well studied during pregnancy, If you’re pregnant or thinking of becoming pregnant, discuss the risks and benefits of using Fluticasone/Salmeterol with your provider.

• Advair Diskus
• Advair HFA