alglucosidase alfa
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Manufactured by various FDA-approved generic manufacturers.
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alglucosidase alfa Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is alglucosidase alfa available in?
alglucosidase alfa is available as a 5 mg/mL solution.
What is alglucosidase alfa used for?
alglucosidase alfa is an enzyme replacement therapy used to treat Pompe disease.
How does alglucosidase alfa work?
alglucosidase alfa is an enzyme replacement therapy. It replaces an enzyme (protein) that helps the body break down a large sugar called glycogen. People with Pompe disease aren’t able to break down glycogen because they’re either missing that enzyme or the enzyme doesn’t work. So glycogen can build up in the body and cause problems, especially in the muscles. alglucosidase alfa replaces the enzyme, which allows the body to break down glycogen and use it for energy.
How do I take alglucosidase alfa?
The recommended dosage of alglucosidase alfa is 20 mg/kg body weight administered every 2 weeks as an intravenous infusion.
Is it safe for me to take alglucosidase alfa?
alglucosidase alfa is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
alglucosidase alfa Common Side Effects
Common side effects of alglucosidase alfa:
- Infants:
- Rash
- Fever
- Hives
- Flushing
- Cough
- Fast breathing
- Fast heart rate
- Children and adults:
- Excessive sweating
- Hives
- Chest discomfort
- Muscle twitching
alglucosidase alfa Serious Side Effects
Serious side effects are rare with alglucosidase alfa. Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic and skin reactions: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing
Effects of other drugs, drug classes and over-the-counter products on alglucosidase alfa
- There are no major drug interactions listed for alglucosidase alfa. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes alglucosidase alfa?
Various FDA-approved generic manufacturers
Is alglucosidase alfa safe in pregnancy?
It is not known if alglucosidase alfa will harm your unborn baby. Tell your healthcare provider if you become pregnant while taking alglucosidase alfa. Patients and their caregivers should be informed that a registry for patients with Pompe disease (the Pompe Registry) has been established in order to better understand the variability and progression of Pompe disease, and to continue to monitor and evaluate long-term treatment effects of alglucosidase alfa. The Pompe Registry will also monitor the effect of alglucosidase alfa on pregnant women and their offspring [see Use in Specific Populations (8)]. Patients and their caregivers are encouraged to participate in the Pompe Registry and advised that their participation is voluntary and may involve long-term follow-up. For more information regarding the registry program call 1-800-745-4447.
What to do if you missed your alglucosidase alfa dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
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