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Myozyme is the brand name for alglucosidase alfa and is available as an intravenous infusion.

Myozyme is available in a strength of 5 mg/mL.

Myozyme is an enzyme replacement therapy for use in patients with Pompe disease (GAA deficiency).

Myozyme replaces an enzyme (protein) that helps the body break down a large sugar called glycogen. People with Pompe disease aren’t able to break down glycogen because they’re either missing that enzyme or the enzyme doesn’t work. So glycogen can build up in the body and cause problems, especially in the muscles.

The recommended dosage of Myozyme is 20 mg/kg body weight administered every 2 weeks as an intravenous infusion.

Myozyme is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Myozyme:

• Rash
• Fever
• Hives
• Flushing
• Cough
• Fast breathing
• Fast heart rate
• Excessive sweating
• Chest discomfort
• Muscle twitching

Serious side effects are rare with Myozyme. Contact your healthcare provider immediately if you experience any of the following:

• Serious allergic and skin reactions: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

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It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Alglucosidase Alfa