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Aklief is the brand name for trifarotene and is available as a topical cream application.

Aklief is available as a 0.005% cream application.

Aklief (trifarotene) is a prescription topical retinoid cream approved for the treatment of acne vulgaris in individuals aged 9 years and older. It is particularly effective for both facial and truncal acne, including areas such as the chest, shoulders, and back.

Aklief is a retinoid; specifically, a fourth-generation elective retinoic acid receptor (RAR)-γ agonist that helps accelerate the skin’s natural cell turnover, exfoliating dead cells and helping to prevent new acne breakouts. It may also reduce the inflammation commonly associated with pimples.

Aklief (trifarotene) is a prescription topical retinoid used to treat acne vulgaris on the face, chest, shoulders, and back. To use it effectively and safely, follow these steps:

Step 1: Cleanse

• Wash the affected areas with a mild or soap-free cleanser.
• Gently pat the skin dry.

Step 2: Apply Aklief

• Apply once daily in the evening.
• Use a thin layer:
  • Face: 1 pump (covers forehead, cheeks, nose, and chin).
  • Upper trunk (shoulders, chest, upper back): 2 pumps.
  • Middle/lower back: 1 additional pump if needed.
• Avoid contact with eyes, lips, mouth, corners of the nose, and mucous membranes.
• Wash your hands after application.

Step 3: Moisturize

• Apply a moisturizer as needed to minimize dryness and irritation.
• You can apply it before or after Aklief; ensure the skin is dry between applications.

Step 4: Protect from Sunlight

• Minimize sun exposure.
• Use sunscreen with SPF 15 or higher and wear protective clothing over treated areas.

Additional Tips

• Do not apply to cuts, abrasions, sunburned skin, or areas affected by eczema.
• Avoid using other skin products that may cause irritation, such as medicated or abrasive soaps and cleansers, products with high alcohol content, or other acne treatments unless directed by your healthcare provider.
• Avoid waxing on treated areas.
• If you miss a dose, apply it the next evening. Do not double up on doses.

Aklief is a safe and effective treatment when used for FDA-licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Most side effects are mild and tend to diminish with continued use. Side effects of Aklief may include:

• Redness (erythema)
• Dryness
• Scaling
• Stinging or burning sensation
• Itching (pruritus)
• Sunburn

Serious side effects are rare with Aklief. Contact your healthcare provider immediately if you experience any of the following.

• Severe Skin Irritation: This can manifest as intense redness, burning, stinging, scaling, or swelling at the application site. These reactions are more common during the initial weeks of treatment and may decrease over time.
• Increased Sensitivity to Sunlight: Aklief can heighten your skin’s sensitivity to ultraviolet (UV) light, leading to a higher risk of sunburn. It’s advisable to minimize sun exposure and use sunscreen with a high SPF. Medical News Today
• Allergic Reactions: Though rare, some individuals may experience allergic reactions, including skin rash, itching, hives, or swelling of the face, lips, tongue, or throat.

Other Topical Retinoids: Using Aklief alongside other topical retinoids (e.g., tretinoin, adapalene) can increase skin irritation.

Benzoyl Peroxide Products: Combining Aklief with benzoyl peroxide may lead to excessive skin dryness and irritation.

Salicylic Acid Products: Concurrent use with salicylic acid can enhance skin irritation.

Isotretinoin (Oral Retinoid): Using Aklief with isotretinoin may increase the risk of skin irritation.

Photosensitizing Agents: Medications like aminolevulinic acid, methoxsalen, porfimer, and verteporfin can increase sensitivity to sunlight when used with Aklief.

Astringents and Abrasive Products: Products such as medicated or abrasive soaps, cleansers, and cosmetics with strong skin-drying effects can exacerbate skin irritation when used with Aklief.

Galderma Laboratories, L.P.

It is not known if Aklief will harm your unborn baby. If you become pregnant while receiving Aklief, talk to your healthcare provider since the data are limited, and caution is advised.

• Trifarotene