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Zegalogue is the brand name for dasiglucagon and is available as a subcutaneous injection.

Zegalogue is available as a 0.6 mg/0.6 mL single-dose autoinjector and a 0.6 mg/0.6 mL single-dose prefilled syringe.

Zegalogue is an anti-hypoglycemic and is used for emergency treatment of very low blood sugar in people age 6 years and older.

Zegalogue is a glucagon receptor agonist that works to raise blood sugar (glucose) levels. It does this by triggering your liver to make more glucose and by breaking down glycogen (a stored form of glucose) in your body.

Zegalogue is typically dosed as 0.6 mg injected under the skin as needed for very low blood sugar. If your blood sugar doesn’t rise after 15 minutes, you can repeat the dose once.

Zegalogue is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:

• Pheochromocytoma
• Insulinoma

Common side effects of Zegalogue:

• Adults:
• Nausea
• Vomiting
• Headache
• Diarrhea
• Injection site pain
• Children:
• Nausea
• Vomiting
• Headache
• Injection site pain

Serious side effects are rare with Zegalogue. Contact your healthcare provider immediately if you experience any of the following.

• High blood pressure: headaches, blurred vision, chest pain, trouble breathing
• Low blood sugar: feeling shaky or hungry, being nervous or anxious, fast heartbeat, sweating or body chills, confusion, feeling sleepy, weakness, low energy
• Serious allergic reactions: trouble breathing, low blood pressure, hives, swelling of your face, lips, tongue, or throat

The following medications may interact with Zegalogue:

• Beta-blockers: Patients taking beta-blockers may have a transient increase in pulse and blood pressure
• Indomethacin: In patients taking indomethacin, Zegalogue may lose its ability to raise blood glucose or may produce hypoglycemia
• Warfarin: Zegalogue may increase the anticoagulant effect of warfarin

Novo Nordisk Inc.

It is not known if Zegalogue can harm your unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Dasiglucagon