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Vpriv is the brand name for velaglucerase alfa and is available as an IV infusion.

Vpriv is available as a 200 Units and 400 Units single-use vial for IV infusion.

Vpriv is a hydrolytic lysosomal glucocerebrosidase-specific enzyme and is used to treat type 1 Gaucher disease in adults and children 4 years of age or older.

Vpriv is a modified (lab-made) version of the enzyme glucocerebrosidase that is normally found in the body. People with Gaucher disease don’t have enough of this enzyme, which breaks down a fatty substance called glucocerebroside. As a result, there are higher levels of glucocerebroside in the body, and it can build up in the spleen, liver, and bones. Vpriv works as an enzyme replacement for glucocerebrosidase and helps your body break down glucocerebroside.

Vpriv is an intravenous (IV) infusion that is administered by a healthcare provider. The dose depends on your weight.

If you haven’t been treated before (treatment naive): In general, the typical starting dose is 60 units/kg once every other week.

If you’re switching from Cerezyme (imiglucerase): The usual starting dose of Vpriv (velaglucerase alfa) is the same dose of Cerezyme (imiglucerase) you were previously using.

Vpriv is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Vpriv:

• Headache
• Fever
• Dizziness
• Stomach pain
• Back pain
• Knee pain
• Fatigue
• Nausea

Serious side effects are rare with Vpriv. Contact your healthcare provider immediately if you experience any of the following.

Serious allergic reactions: throat tightness, trouble breathing, cough, itching or hives, flushing, swelling, chest pain, fast heartbeat, dizziness, fainting

No drug-drug interaction studies have been conducted with Vpriv. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

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It is not known if Vpriv can harm your unborn baby.
Vpriv should only be used during pregnancy if the benefit to you is worth the possible risk to your baby.

• Velaglucerase Alfa