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Venclexta is the brand name for venetoclax oral tablets.

Venclexta is available as a 10 mg, 50 mg, or 100 mg oral tablet.

Venclexta is a targeted therapy (BCL2 Inhibitors) and is used for the following:

• Acute myeloid leukemia (AML) in older adults or people with certain medical conditions
• Chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in adults

Venclexta is a type of targeted therapy called a BCL-2 inhibitor. BCL-2 is a protein that helps cancer cells survive. Certain cancers, like AML and CLL/SLL, have too many BCL-2 proteins. This allows them to continue growing uncontrollably. Venclexta works by targeting and blocking BCL-2 on cancer cells, which allows it to kill and slow down the growth of cancer cells.

Venclexta is dosed as follows: Your provider might prescribe other anticancer medications for you to take along with Venclexta. Make sure to ask your provider about the specific directions and dosing of all the medications of your treatment plan. Your dose of Venclexta might differ depending on whether you’re experiencing side effects or if you’ve any kidney or liver problems.

AML

• The typical starting dose for Venclexta is 100 mg by mouth daily. Your provider will raise your dose daily over 3 to 4 days until you reach the maintenance dose of 400 mg or 600 mg daily, depending on which other anticancer medications you’re taking with Venclexta

CLL or SLL

• The typical starting dose for Venclexta is 20 mg by mouth daily. Your provider will raise your dose every week during your first 5 weeks of treatment until you reach a maintenance dose of 400 mg daily

Venclexta is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a strong CYP3A inhibitors at initiation and during rampup phase with CLL/SLL.

Common side effects of Venclexta:

• Low white blood cell count
• Diarrhea
• Nausea
• Upper respiratory tract infection
• Low red blood cell count
• Tiredness
• Low platelet count
• Muscle and joint pain
• Swelling in arms, legs, hands, or feet
• Stomach pain
• Headache
• Rash
• Vomiting
• Constipation

Serious side effects are rare with Venclexta. Contact your healthcare provider immediately if you experience any of the following.

• Tumor lysis syndrome: fever, chills, nausea or vomiting, confusion, shortness of breath, seizures, irregular heartbeat, dark or cloudy urine, muscle or joint pain, unusual tiredness
• Serious infections: body aches, chills, fever, headache, new cough, sore throat, feeling tired

The following medications may interact with Venclexta:

• Strong or moderate CYP3A inhibitors or P-gp inhibitors: Adjust dosage of Venclexta
• Strong or moderate CYP3A inducers: Avoid co-administration
• P-gp substrates: Take at least 6 hours before Venclexta

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Venclexta may harm your unborn baby. If you are able to become pregnant, your healthcare provider should do a pregnancy test before you start treatment with Venclexta.
Females who are able to become pregnant should use effective birth control during treatment and for 30 days after the last dose of Venclexta. If you become pregnant or think you are pregnant, tell your healthcare provider right away.

• Venetoclax