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Vabysmo is the brand name for faricimab-svoa and is given as an eye injection.

Vabysmo is available as a 120 mg/mL solution in a single-dose vial.

Vabysmo is a VEGF and Ang-2 inhibitor and is used for the following:

• Neovascular (wet) age-related macular degeneration (nAMD)
• Diabetic macular edema (DME)

Vabysmo is an injectable medication that blocks two proteins called vascular endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2). VEGF-A and Ang-2 promote abnormal blood vessel growth, swelling, and fluid leakage. In neovascular (wet) age-related macular degeneration (nAMD) and diabetic macular edema (DME), the effects of these two proteins cause damage to parts of the eye that are important for vision. This damage can lead to vision loss. Blocking both VEGF-A and Ang-2 with Vabysmo leads to less abnormal blood vessel growth and swelling in the back of the eye.

Vabysmo is dosed as follows:
Neovascular (wet) age-related macular degeneration: The typical dose is 6 mg injected into the eye every 4 weeks for the first 4 doses. Then, your provider will determine how many additional doses you need and how often you’ll get them based on your eye exams. Diabetic macular edema: The typical dose is 6 mg injected into the eye every 4 weeks for the first 4 or 6 doses. Then, your provider will determine how often you need to get your following doses based on your eye exams.

Vabysmo is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following.

• Ocular or periocular infection
• Active intraocular inflammation
• Hypersensitivity

Common side effects of Vabysmo:

• Blood on the white of the eye
• Eye floaters
• Tear in the retina
• Raised eye pressure
• Eye pain
• Eye inflammation

Serious side effects are rare with Vabysmo. Contact your healthcare provider immediately if you experience any of the following.

• Eye infection or retinal detachment: eye redness, eye pain, light sensitivity, vision changes
• Stroke: sudden numbness or weakness on one side of the body; sudden confusion; trouble speaking, seeing, or walking; sudden severe headache
• Heart attack: chest pain or discomfort; weakness or lightheadedness; shortness of breath; pain or discomfort in the jaw, neck, back, arms or shoulders

• There are no major drug interactions listed for Vabysmo. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Genentech, Inc.

There are no adequate and well-controlled studies of Vabysmo administration in pregnant women.Vabysmo should not be used during pregnancy unless the potential benefit to the patient outweighs the potential risk to the fetus.

• Faricimab