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MEDICAL INFORMATION
Tryvio Key Facts
What is Tryvio?
Tryvio (aprocitentan) is an oral tablet used to treat high blood pressure.
What dosages is Tryvio available in?
Tryvio is available as a 12.5 mg oral tablet.
What is Tryvio used for?
Tryvio is an endothelin receptor antagonist indicated for the treatment of hypertension in combination with other antihypertensive medications to lower blood pressure in adult patients who are not adequately controlled on other drugs.
How does Tryvio work?
Tryvio is an endothelin receptor antagonist (ERA). It blocks the action of endothelin-1, a substance in the body that narrows the blood vessels and causes high blood pressure. Blocking the action of this substance relaxes the blood vessels in the body, which lead to lower blood pressure and easier blood flow to the heart.
How do I take Tryvio?
Tryvio is given as 12.5 mg by mouth once daily, with or without food.
Is it safe for me to take Tryvio?
Tryvio is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you are pregnant or are allergic to aprocitentan or any inactive ingredients in the product.
Tryvio Common Side Effects
Common side effects of Tryvio: Edema (fluid build up in the body, swelling) Anemia
Tryvio Serious Side Effects
Serious side effects are rare with Tryvio. Contact your healthcare provider immediately if you experience any of the following: Fluid build up in the body: shortness of breath; swelling in the legs, ankles, or feet; irregular heartbeat; chest pain; not able to exercise; tiredness; unusual weight gain Liver injury: loss of appetite, nausea, vomiting, stomach pain in the upper right side, dark urine, fever, yellowing of the skin or whites of the eyes Anemia (low red blood cell count): tiredness, shortness of breath, irregular heartbeat, dizziness, chest pain, pale skin Allergic reaction: rash, red skin, swelling
Effects of other drugs, drug classes and over-the-counter products on Tryvio
There are no drug interactions listed for Tryvio.
Who makes Tryvio?
Idorsia Ltd.
Is Tryvio safe in pregnancy?
Based on animal reproduction studies with other ERAs, Tryvio can cause harm to your unborn baby, including birth defects and fetal death. Because of this Tryvio is contraindicated during pregnancy
What is the generic name for Tryvio?
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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We are a broad skilled and passionate group of clinicians with experience of operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process
Ketan Patel
Pharmacist Independent Prescriber, Pharmacist
Daniel Cheung
Pharmacist Independent Prescriber, Pharmacist
DeLon Canterbury
US Board Certified Pharmacist/PGX & Deprescribing Specialist
Navin Khosla
UK Responsible Person (UKRP), Pharmacist Independent Prescriber, Clinical Safety Officer (CSO), Pharmacist
Amish Patel
Pharmacist Independent Prescriber, Superintendant Pharmacist, Pharmacist
Stefano Mirabello
Pharmacist Independent Prescriber, Clinical Safety Officer (CSO), Pharmacist
Rajive Patel
Medical Writer
Ihtesham Sabri
Medical Director
Monica Khosla
Medical Writer
Jamie Winn
US Board Certified Pharmacist
Aseel Hamoud Bedan
Hospital Consultant