trientine hydrochloride
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Manufactured by various FDA-approved generic manufacturers.
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trientine hydrochloride Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is trientine hydrochloride available in?
trientine hydrochloride is available as a 250 mg oral capsule.
What is trientine hydrochloride used for?
trientine hydrochloride is a chelating agent and is used to treat Wilson’s disease in people who can’t take penicillamine (Depen).
How does trientine hydrochloride work?
trientine hydrochloride is a chelating agent, which means that it attaches to certain metals to help remove them from the body. In Wilson’s disease, high amounts of copper get stored in different parts of your body, such as the liver and brain. By attaching to this extra copper, trientine hydrochloride prevents the copper from being absorbed into your body. This helps keep your blood copper levels low.
How do I take trientine hydrochloride?
trientine hydrochloride is dosed as follows:
- Adults and children older than 12 years: The typical starting dose is 750 mg to 1,250 mg by mouth per day. The maximum dose is 2,000 mg per day
- Children age 12 years and younger: The typical starting dose is 500 mg to 750 mg by mouth per day. The maximum dose is 1,500 mg per day
- The total daily dose of trientine hydrochloride is typically separated into 2 to 4 doses throughout the day. Your provider will adjust the dose based on any side effects you experience with the medication, your Wilson’s disease symptoms, and your blood copper levels
Is it safe for me to take trientine hydrochloride?
trientine hydrochloride is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
trientine hydrochloride Common Side Effects
Common side effects of trientine hydrochloride:
- Low iron levels
trientine hydrochloride Serious Side Effects
Serious side effects are rare with trientine hydrochloride. Contact your healthcare provider immediately if you experience any of the following.
- Myasthenia gravis: periods of muscle weakness, eyelid drooping, changes in vision or speech, difficulty swallowing
- Systemic lupus erythematosus (SLE): on-and-off fever, tiredness, skin rash across cheeks and nose (butterfly rash), joint pain
Effects of other drugs, drug classes and over-the-counter products on trientine hydrochloride
The following medications may interact with trientine hydrochloride:
In general, mineral supplements should not be given since they may block the absorption of trientine hydrochloride. However, iron deficiency may develop, especially in children and menstruating or pregnant women, or as a result of the low copper diet recommended for Wilson’s disease. If necessary, iron may be given in short courses, but since iron and trientine hydrochloride each inhibit absorption of the other, two hours should elapse between administration of trientine hydrochloride and iron. It is important that trientine hydrochloride be taken on an empty stomach, at least one hour before meals or two hours after meals and at least one hour apart from any other drug, food, or milk. This permits maximum absorption and reduces the likelihood of inactivation of the drug by metal binding in the gastrointestinal tract.
Who makes trientine hydrochloride?
Various FDA-approved generic manufacturers
Is trientine hydrochloride safe in pregnancy?
There are no adequate and well-controlled studies in pregnant women. trientine hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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