SYPRINE

Trientine is prescribed to address Wilson’s disease, an inherited disorder that leads to excessive copper accumulation in the liver, brain, and other body parts. Trientine functions by attaching to copper, aiding the body in eliminating excess copper.

SYPRINE (Trientine Hydrochloride) is provided in the form of 250 mg capsules that can be taken orally. The capsules of SYPRINE consist of gelatin, iron oxides, stearic acid, and titanium dioxide as inactive components.

Typically, the symptoms of Wilson’s disease emerge during the ages of 12 to 23, and individuals who do not receive treatment may have a life expectancy of 40 years. Nevertheless, if diagnosed early and treated appropriately, the lifespan can be extended.

Wilson disease can be fatal without medical intervention, but it can be managed with treatment. While there is no cure, options such as medications, chelation therapy, and avoiding copper-rich foods can help control the condition.

Cuvrior is used to treat stable Wilson’s disease in adults who have already undergone copper removal and are able to tolerate penicillamine. Syprine is used to treat Wilson’s disease in patients who cannot tolerate penicillamine.

SYPRINE is a registered trademark owned by Bausch Health Companies Inc. or its affiliates.

Mechanism of Action: Trientine hydrochloride acts as a chelating agent, aiding in the removal of excess copper from the body. This is particularly beneficial in cases of Wilson disease, a metabolic disorder inherited in an autosomal recessive manner. The accumulation of excess copper in the body is believed to be caused by the liver’s inability to eliminate free copper into the bile.

This drug is classified as an anticonvulsant or anti-epileptic medication. It is also prescribed for the relief of specific nerve pain conditions, such as trigeminal neuralgia. Its mechanism of action involves reducing the propagation of seizure activity in the brain and restoring the normal equilibrium of nerve activity.

Not recommended as a substitute for penicillamine in the treatment of rheumatoid arthritis or cystinuria. Should not be used for conditions without elevated free copper levels. May decrease serum iron levels, potentially by decreasing absorption.

Each capsule of trientine HCl, USP contains 250 mg of trientine HCl, USP and stearic acid as an inactive ingredient.

Valeant increased the prices of Syprine and Cuprimine, despite not investing in research and development or experiencing higher manufacturing costs. The motive behind this price hike was simply greed.

Zolgensma, also known as onasemnogene abeparvovec-xioi, is a gene therapy that has been approved to treat Spinal Muscular Atrophy (SMA) in children under the age of 2. This life-saving treatment involves a single-dose intravenous infusion, and it comes with a hefty price tag of $2.125 million.

Syprine, a medication used to treat the rare condition Wilson disease, became widely known when Valeant Pharmaceuticals International increased its price from $652 to $21,267 in 2015, a significant jump within just five years.

Sylvant (siltuximab) belongs to the drug class of interleukin inhibitors and is often prescribed for Multicentric Castleman’s Disease. The price for a supply of 1 powder for injection of Sylvant intravenous 100 mg can range from around $1,549, depending on the pharmacy.

The most expensive medication on the list is tadalafil, with an average 30-day price of $518. Following closely behind are zolpidem, diclofenac sodium, estradiol, sildenafil, celecoxib, valacyclovir, and amphetamine salt combo XR.

Cost and Availability: Mipomersen is sold in single-use 1-mL vials with a concentration of 200 mg/mL. The average wholesale price (AWP) for one week of mipomersen therapy is $5,759.65, while the AWP for a 30-day supply is $23,038.60.

Trientine (brand name Syprine): Indications, Adverse Effects, Dosage, and User Reviews.

Trientine is a highly effective treatment for hepatic Wilson’s disease, even in challenging cases such as patients with decompensated cirrhosis. Unlike d-penicillamine, trientine has very few adverse effects, although there is a rare possibility of neurological worsening.

On October 24, 2003, the European Commission granted orphan designation (EU/3/03/172) to Univar Limited, a company based in the United Kingdom. This designation was granted for the use of trientine dihydrochloride in the treatment of Wilson’s disease.

Trientine Waymade is a medication that contains trientine dihydrochloride as its active ingredient. It is prescribed for the treatment of Wilson’s disease in individuals who are unable to tolerate penicillamine due to its side effects.

Ipratropium bromide is the generic term for Atrovent HFA.

Trientine, an oral copper chelating agent, is prescribed for the treatment of Wilson disease. It has not been linked to any deterioration in serum enzyme levels or instances of liver injury accompanied by jaundice.

Search savings options using NowPatient. Syprine Coupons, Prices, and Savings Card are available for this medication. Syprine is used to treat Wilson’s disease, an inherited disorder. It is an oral generic drug. The average price for a 30-day supply of 250MG Capsules (30 Capsules) of the generic version (trientine) is $391.69.

The price of a 100-capsule supply of Syprine oral capsules 250 mg can vary depending on the pharmacy, but it is typically around $22,403.

BRANDFORM.trientine oral -250 mg capsuleSyprine oral -250 mg capsule

The price of trientine oral capsule 250 mg is approximately $6,433 for a 100-capsule supply, but this may vary depending on the pharmacy you choose. Please note that the quoted prices are for customers paying in cash and may not be applicable with insurance plans.

Valeant Pharmaceuticals North America LLC holds the registered trademark for Syprine®.

Syprine is priced at $200 per 250-mg capsule, while Cuprimine costs between $55 and $60 per 250-mg tablet. The average daily adult dose of Syprine is 1,000 mg, which results in an annual cost of $300,000, making it the most expensive liver disease treatment available.

The price of a 30-day supply of pioglitazone oral tablets 15 mg can vary, but it is typically around $11, depending on the pharmacy you choose.

Valeant’s business model was based on minimizing spending on research and development, opting instead to acquire drugs and increase prices. However, this approach ultimately led to its downfall as the company neglected to prioritize drug development, leaving it vulnerable to failure.

Syprine and generic capsules of trientine are both available in 250 mg doses.

TreatmentStrength / concentrationAnnual costTrientine (MAR-Trientine)250 mgAdult: $21,900 to $58,400 Adolescent (13 to 17): $14,600 to $58,400 Child (5 to 12): $14,600 to $43,800Other ChelatorD-penicillamine (Cuprimine)250 mg$4,342 to $11,578Zinc supplementation

Tegretol (carbamazepine) belongs to the dibenzazepine anticonvulsants drug class and is often prescribed for Epilepsy, Schizoaffective Disorder, and Trigeminal Neuralgia. The price for Tegretol oral suspension (100 mg/5 mL) is approximately $208 for 450 milliliters, but may vary depending on the pharmacy.

Penicillamine functions by reducing cystine levels in the urine and can also be utilized to address rheumatoid arthritis when other drugs are ineffective or cannot be tolerated. With a NowPatient Rx Advantage Card, you can obtain penicillamine for as little as $586.50, a 96% discount from the average retail price of $13,415.65 for the most commonly prescribed version.