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Tribenzor is the brand name for olmesartan, amlodipine, and hydrochlorothiazide oral tablets.

Tribenzor is available as a combination of olmesartan, amlodipine, and hydrochlorothiazide and is available in strengths of: 20 mg/5 mg/12.5 mg, 40 mg/5 mg/12.5 mg, 40 mg/5 mg/25 mg, 40 mg/10 mg/12.5 mg, and 40 mg/10 mg/25 mg.

Tribenzor is an ARB / CCB / Diuretic (water pill) and is used to treat high blood pressure.

Tribenzor is a combination of three medications that lower blood pressure. Olmesartan is an angiotensin II receptor blocker (ARB). Angiotensin II is a hormone that normally attaches to its signaling proteins (receptors) in the body to raise your blood pressure. Olmesartan blocks this interaction from happening to lower your blood pressure. Amlodipine is a calcium channel blocker (CCB). It works by relaxing your blood vessels to lower your blood pressure. Hydrochlorothiazide is a thiazide diuretic (water pill). It works in your kidneys to remove extra water and certain electrolytes, like sodium and potassium. This helps lower blood pressure.

The typical starting dose for Tribenzor is 20 mg/5 mg/12.5 mg (olmesartan/amlodipine/hydrochlorothiazide) by mouth once daily. Your provider will adjust your dose based on how well it’s helping your blood pressure and if you’re having side effects. The maximum dose is 40 mg/10 mg/25 mg (olmesartan/amlodipine/hydrochlorothiazide) once daily.

Tribenzor is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have

Common side effects of Tribenzor:

• Dizziness
• Swelling of legs or arms
• Headache
• Tiredness
• Runny nose, sore throat, and other cold-like symptoms

Serious side effects are rare with Tribenzor. Contact your healthcare provider immediately if you experience any of the following.

• Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint or fainting
• Heart attack: tightness and pain in the chest, neck, arms, or back; cold and clammy skin; sweating; dizziness; tiredness
• Kidney problems: urinating less often than usual; swelling in your feet, ankles, or hands; unexplained weight gain
• High blood potassium levels: nausea, muscle weakness, abnormal heartbeat
• Severe diarrhea

The following medications may interact with Tribenzor:

Olmesartan medoxomil:

• Nonsteroidal anti-inflammatory drugs (NSAIDS): May lead to increased risk of renal impairment and loss of antihypertensive effect.
• Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia.

Amlodipine:

• If simvastatin is co-administered with amlodipine, do not exceed doses
• greater than 20 mg daily of simvastatin.

Hydrochlorothiazide:

• Alcohol, barbiturates, narcotics: Potentiation of orthostatic hypotension
• Antidiabetic drugs: Dosage adjustment of antidiabetic may be required
• Cholestyramine and colestipol: Reduced absorption of thiazides
• Corticosteroids, ACTH: Electrolyte depletion, hypokalemia
• Lithium: Reduced renal clearance and high risk of lithium toxicity when used with diuretics. Should not be given with diuretics
• NSAIDs: Can reduce the diuretic, natriuretic, and antihypertensive effects of diuretics

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Tribenzor can cause harm or death to an unborn baby.
Talk to your doctor about other ways to lower your blood pressure if you plan to become pregnant. If you get pregnant while taking Tribenzor, tell your doctor right away.

• Olmesartan/Amlodipine