View TRI-CYCLEN savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or TRI-CYCLEN Patient Assistance Program.

Programs are suitable for individuals who want to buy TRI-CYCLEN without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Janssen Pharmaceuticals

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about TRI-CYCLEN



TRI-CYCLEN is the brand name for norgestimate/ethinyl estradiol and is available as an oral tablet.

What dosages is TRI-CYCLEN available in?

What dosages is TRI-CYCLEN available in?

TRI-CYCLEN is available as an oral tablet that contains a combination of norgestimate and ethinyl estradiol.

What is TRI-CYCLEN used for?

What is TRI-CYCLEN used for?

TRI-CYCLEN is a combination of a progestin and estrogen that is used:

  • To prevent pregnancy
  • Treatment of moderate acne
How does TRI-CYCLEN work?

How does TRI-CYCLEN work?

TRI-CYCLEN is a combination medication that contains two hormones, norgestimate (a progestin) and ethinyl estradiol (an estrogen). Both hormones work together to prevent pregnancy by:

  • Suppressing ovulation (release of an egg from the ovary)
  • Changing cervical mucus to block sperm movement
  • Creating an unfriendly environment for the fertilized egg by changing the lining in the uterus (womb)
  • TRI-CYCLEN can also be used to treat acne. This medication helps with acne by lowering the amount of testosterone (a hormone) in your body. This leads to less oil production and less clogging of the pores of the skin.
How do I take TRI-CYCLEN?

How do I take TRI-CYCLEN?

TRI-CYCLEN comes in a 28-day pack. Your medication might look different depending on which branded generic your provider prescribes. Please take the medication as instructed by your provider or following the directions on the package. In general:

  • Day 1 through 7: 0.18 mg norgestimate and 35 mcg ethinyl estradiol
  • Day 8 through 14: 0.215 mg norgestimate and 35 mcg ethinyl estradiol
  • Day 15 through 21: 0.25 mg norgestimate and 35 mcg ethinyl estradiol
  • Day 22 through 28: Placebo tablets (hormone-free)

The typical dose is 1 tablet by mouth at the same time every day for 28 days, following the order as instructed on the package.

Is it safe for me to take TRI-CYCLEN?

Is it safe for me to take TRI-CYCLEN?

TRI-CYCLEN is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following: Thrombophlebitis or thromboembolic disorders A past history of deep vein thrombophlebitis or thromboembolic disorders
Known thrombophilic conditions Cerebral vascular or coronary artery disease (current or past history)
Valvular heart disease with complications
Persistent blood pressure values of 160 mm Hg systolic or 100 mg Hg diastolic Diabetes with vascular involvement
Headaches with focal neurological symptoms Major surgery with prolonged immobilization Known or suspected carcinoma of the breast or personal history of breast
cancer Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia Undiagnosed abnormal genital bleeding Cholestatic jaundice of pregnancy or jaundice with prior pill use Acute or chronic hepatocellular disease with abnormal liver function Hepatic adenomas or carcinomas Known or suspected pregnancy Hypersensitivity to any component of this product

TRI-CYCLEN Common Side Effects

TRI-CYCLEN Common Side Effects

Common side effects of TRI-CYCLEN:

  • Headache or migraine
  • Breast changes (tenderness, enlargement)
  • Vaginal infection
  • Stomach pain
  • Mood changes
  • Vaginal discharge
  • Changes in weight
TRI-CYCLEN Serious Side Effects

TRI-CYCLEN Serious Side Effects

Serious side effects are rare with TRI-CYCLEN. Serious Side Effects Contact your healthcare provider immediately if you experience any of the following.

  • Heart attack: chest pain, stomach discomfort, sweating, nausea, dizziness
  • Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, difficulty walking
  • Deep vein thrombosis (blood clot in the leg): leg cramp, swelling, pain, muscle tightness
  • Pulmonary embolism (blood clot in the lung): cough, chest pain, trouble breathing, racing heart
Effects of other drugs, drug classes and over-the-counter products on TRI-CYCLEN

Effects of other drugs, drug classes and over-the-counter products on TRI-CYCLEN

  • No drug-drug interaction studies were conducted with TRI-CYCLEN. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes TRI-CYCLEN?

Who makes TRI-CYCLEN?

Janssen Pharmaceuticals

Is TRI-CYCLEN safe in pregnancy?

Is TRI-CYCLEN safe in pregnancy?

TRI-CYCLEN should not be used during pregnancy.


What to do if you missed your TRI-CYCLEN dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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